Mechanisms underlying the development of type 1 diabetes in ART-treated people living with HIV: an enigmatic puzzle

The immunopathogenesis of HIV infection remains poorly understood. Despite the widespread use of effective modern antiretroviral therapy (ART), people living with HIV (PLWH) are known to develop several comorbidities, including type 1 diabetes (T1DM). However, the etiology and critical mechanisms ac...

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Published inFrontiers in immunology Vol. 15; p. 1470308
Main Authors Zaongo, Silvere D., Zongo, Abel W., Chen, Yaokai
Format Journal Article
LanguageEnglish
Published Switzerland Frontiers Media S.A 27.08.2024
Subjects
Anti-HIV Agents - therapeutic use
Anti-Retroviral Agents - therapeutic use
antiretroviral therapy
Diabetes Mellitus, Type 1 - drug therapy
Diabetes Mellitus, Type 1 - immunology
HIV
HIV Infections - complications
HIV Infections - drug therapy
HIV Infections - immunology
HIV-1 - immunology
Humans
Immunology
mechanisms
T1DM
type 1 diabetes
T1DM
type 1 diabetes
ART
HIV
mechanisms
antiretroviral therapy
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ISSN1664-3224
1664-3224
DOI10.3389/fimmu.2024.1470308

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Summary:The immunopathogenesis of HIV infection remains poorly understood. Despite the widespread use of effective modern antiretroviral therapy (ART), people living with HIV (PLWH) are known to develop several comorbidities, including type 1 diabetes (T1DM). However, the etiology and critical mechanisms accounting for the onset of T1DM in the preceding context remain unknown. This article proposes to address this topic in order to provide further understanding and future research directions.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
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ObjectType-Review-3
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Edited by: Mohamed Mahdi, University of Debrecen, Hungary
Reviewed by: Sumon Rahman Chowdhury, Bangladesh Institute of Research and Rehabilitation for Diabetes Endocrine and Metabolic Disorders (BIRDEM), Bangladesh
David Wagner, University of Colorado Anschutz Medical Campus, United States
ISSN:1664-3224
1664-3224
DOI:10.3389/fimmu.2024.1470308