Occipital Cortical Thickness Predicts Performance on Pitch and Musical Tasks in Blind Individuals

• Published in: Cerebral cortex (New York, N.Y. 1991) Vol. 22; no. 11; pp. 2455 - 2465
• Main Authors: Voss, P., Zatorre, R. J.
• Format: Journal Article
• Language: English
• Published: United States Oxford University Press 01.11.2012
• Subjects: Adult; Age of Onset; Auditory Perception - physiology; Blindness - pathology; Blindness - psychology; Discrimination (Psychology) - physiology; Female; Humans; Image Processing, Computer-Assisted; Loudness Perception - physiology; Magnetic Resonance Imaging; Male; Middle Aged; Music - psychology; Occipital Lobe - anatomy & histology; Occipital Lobe - pathology; Pitch Discrimination - physiology; Psychomotor Performance - physiology; Regression Analysis; Visual Cortex - pathology
• ISSN: 1047-3211; 1460-2199; 1460-2199
• DOI: 10.1093/cercor/bhr311

The behavioral and neurofunctional consequences of blindness often include performance enhancements and recruitment of occipital regions for nonvisual tasks. How the neuroanatomical changes resulting from this sensory loss relate to these functional changes is, however, less clear. Previous studies using cortical thickness (CT) measures have shown thicker occipital cortex in early-blind (EB) individuals compared with sighted controls. We hypothesized that this finding reflects the crossmodal plasticity often observed in blind individuals and thus could reflect behavioral adaptations. To address this issue, CT measures in blind (early and late) and sighted subjects were obtained along with several auditory behavioral measures in an attempt to relate behavioral and neuroanatomical changes. Group contrasts confirmed previous results in showing thicker occipital cortex in the EB. Regression analyses between CT measures across the whole brain of all blind individuals with the behavioral scores from 2 tasks in which EB subjects were superior (pitch and melody discrimination) showed that CT of occipital areas was directly related to behavioral enhancements. These findings constitute a compelling demonstration that anatomical changes in occipital areas are directly related to heightened behavioral abilities in the blind and hence support the idea that these anatomical features reflect adaptive compensatory plasticity.