Safety and Efficacy of Long-Acting Liposomal Bupivacaine Plus Bupivacaine Hydrochloride for Dorsal Penile Block During Ambulatory Pediatric Urologic Surgery

This study evaluates the tolerability and efficacy of preoperative dorsal penile nerve block with Exparel plus bupivacaine hydrochloride in children>6 years old undergoing ambulatory urologic surgery. We demonstrate that the drug combination is well-tolerated, with appropriate analgesic efficacy...

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Published inUrology (Ridgewood, N.J.) Vol. 176; pp. 190 - 193
Main Authors Gabrielson, Andrew T., Galansky, Logan, Sholklapper, Tamir, Florissi, Isabella, Crigger, Chad, Harris, Kelly, Haney, Nora, Patel, Hiten D., Wang, Ming-Hsien, Wu, Charlotte, Gearhart, John P., Di Carlo, Heather N.
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 01.06.2023
Subjects
Analgesics
Anesthetics, Local
Bupivacaine
Child
Humans
Pain, Postoperative - drug therapy
Pain, Postoperative - prevention & control
Prospective Studies
NPS
PPPM
PACU
FLACC
Exparel
OMEQ
Online AccessGet full text
ISSN0090-4295
1527-9995
1527-9995
DOI10.1016/j.urology.2023.01.056

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Summary:This study evaluates the tolerability and efficacy of preoperative dorsal penile nerve block with Exparel plus bupivacaine hydrochloride in children>6 years old undergoing ambulatory urologic surgery. We demonstrate that the drug combination is well-tolerated, with appropriate analgesic efficacy in the recovery room as well as at 48-hour and 10-14 day follow-up periods. These preliminary data justify the need to perform a prospective, randomized trial comparing Exparel plus bupivacaine hydrochloride to other common local anesthetic regimens used in pediatric urologic surgery.
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ISSN:0090-4295
1527-9995
1527-9995
DOI:10.1016/j.urology.2023.01.056