Chronic kidney disease: Biomarker diagnosis to therapeutic targets

• Published in: Clinica chimica acta Vol. 499; pp. 54 - 63
• Main Authors: Wang, Yan-Ni, Ma, Shi-Xing, Chen, Yuan-Yuan, Chen, Lin, Liu, Bao-Li, Liu, Qing-Quan, Zhao, Ying-Yong
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.12.2019
• Subjects: Animals; Biomarker; Biomarkers - analysis; Biomarkers - metabolism; Chronic kidney disease; Glomerular filtration rate; Humans; Mass spectrometry; Metabolomics; Renal Insufficiency, Chronic - diagnosis; Renal Insufficiency, Chronic - drug therapy; Renal Insufficiency, Chronic - metabolism; Ultra-performance liquid chromatography; ESRD; Metabolomics; Biomarker; Scr; SDMA; GFR; ANOVA; Ultra-performance liquid chromatography; DKD; UPLC-HDMS; CKD; HPLC; eGFR; CLASSY; HILIC-TOF/MS; HCA; OPLS-DA; 1H NMR; ADMA; Chronic kidney disease; Nx; PLS-DA; AAN; UUO; Glomerular filtration rate; PCA; TIF; 5-MTP; LC-MS; TPH-1; NMMA; Cys-C; Mass spectrometry
• ISSN: 0009-8981; 1873-3492; 1873-3492
• DOI: 10.1016/j.cca.2019.08.030

Chronic kidney disease (CKD), characterized as renal dysfunction, is recognized as a major public health problem with high morbidity and mortality worldwide. Unfortunately, there are no obvious clinical symptoms in early stage disease until severe damage has occurred. Further complicating early diagnosis and treatment is the lack of sensitive and specific biomarkers. As such, novel biomarkers are urgently needed. Metabolomics has shown an increasing potential for identifying underlying disease mechanisms, facilitating clinical diagnosis and developing pharmaceutical treatments for CKD. Recent advances in metabolomics revealed that CKD was closely associated with the dysregulation of numerous metabolites, such as amino acids, lipids, nucleotides and glycoses, that might be exploited as potential biomarkers. In this review, we summarize recent metabolomic applications based on animal model studies and in patients with CKD and highlight several biomarkers that may play important roles in diagnosis, intervention and development of new therapeutic strategies. •Chronic kidney disease is a major public problem with high morbidity and mortality.•Potential biomarkers are useful for the diagnosis of chronic kidney disease.•Metabolomics shows the potential for biomarker discovery and clinical diagnosis.•Biomarkers provide new therapeutic strategy for patient with chronic kidney disease.