Application of Helicobacter pylori stool antigen test to survey the updated prevalence of Helicobacter pylori infection in Taiwan

Background and Aim The reported prevalence of Helicobacter pylori infection in Taiwan was 54.4% in 1992. An updated prevalence of H. pylori infection in asymptomatic adults is lacking in Taiwan. We aimed to assess the updated age‐standardized prevalence of H. pylori infection in asymptomatic subject...

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Published inJournal of gastroenterology and hepatology Vol. 35; no. 2; pp. 233 - 240
Main Authors Chen, Mei‐Jyh, Fang, Yu‐Jen, Wu, Ming‐Shiang, Chen, Chieh‐Chang, Chen, Yen‐Nien, Yu, Chien‐Chun, Kuo, Chia‐Chi, Chiu, Min‐Chin, Hu, Wen‐Hao, Tsai, Min‐Horn, Hsieh, Cheng‐Lin, Chen, Hsin‐Hung, Bair, Ming‐Jong, Liou, Jyh‐Ming
Format Journal Article
LanguageEnglish
Published Australia Wiley Subscription Services, Inc 01.02.2020
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ISSN0815-9319
1440-1746
1440-1746
DOI10.1111/jgh.14828

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Summary:Background and Aim The reported prevalence of Helicobacter pylori infection in Taiwan was 54.4% in 1992. An updated prevalence of H. pylori infection in asymptomatic adults is lacking in Taiwan. We aimed to assess the updated age‐standardized prevalence of H. pylori infection in asymptomatic subjects and in patients with dyspepsia and to assess the accuracy of H. pylori stool antigen (HpSA) test for screening of H. pylori in Chinese population. Methods Asymptomatic adult subjects (N = 189) were screened for H. pylori infection using HpSA, serology, and 13C‐urea breath test (13C‐UBT) in 2016–2017. Adult patients with dyspepsia (N = 145) were screened for H. pylori using 13C‐UBT, HpSA, serology, rapid urease test, and histology during 2016–2018. Two types of HpSA, including the Diagnostec HpSA ELISA Kit (HpSA ELISA) and Rapid Test Kit (HpSA Rapid), were used in this study. Sensitivity, specificity, and accuracy of the HpSA tests were calculated using the 13C‐UBT as golden standard test. Results The unadjusted prevalence of H. pylori was 21.2% in asymptomatic adults and 37.9% in patients with dyspepsia (P < 0.001). The age‐standardized prevalence of H. pylori was 28.9% in asymptomatic adults in Taiwan. Of the 334 patients included for analysis, the area under the curve of HpSA ELISA test was 0.978, and the optimal cutoff value of optical density was 0.03. The sensitivity, specificity, and accuracy of the HpSA ELISA were 0.929, 0.983, and 0.967, respectively. The sensitivity, specificity, and accuracy of the HpSA Rapid were 0.929, 0.958, and 0.949, respectively. Conclusions The prevalence of H. pylori infection has decreased in Taiwan. HpSA test is an accurate tool for screening of H. pylori in Chinese population.
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ISSN:0815-9319
1440-1746
1440-1746
DOI:10.1111/jgh.14828