Predicting Survival After Hepatocellular Carcinoma Resection Using Deep Learning on Histological Slides

• Published in: Hepatology (Baltimore, Md.) Vol. 72; no. 6; pp. 2000 - 2013
• Main Authors: Saillard, Charlie, Schmauch, Benoit, Laifa, Oumeima, Moarii, Matahi, Toldo, Sylvain, Zaslavskiy, Mikhail, Pronier, Elodie, Laurent, Alexis, Amaddeo, Giuliana, Regnault, Hélène, Sommacale, Daniele, Ziol, Marianne, Pawlotsky, Jean‐Michel, Mulé, Sébastien, Luciani, Alain, Wainrib, Gilles, Clozel, Thomas, Courtiol, Pierre, Calderaro, Julien
• Format: Journal Article
• Language: English
• Published: United States Wolters Kluwer Health, Inc 01.12.2020
• Subjects: Aged; Algorithms; Artificial intelligence; Carcinoma, Hepatocellular - mortality; Carcinoma, Hepatocellular - pathology; Carcinoma, Hepatocellular - surgery; Deep Learning; Feasibility Studies; Female; Follow-Up Studies; Genomes; Hepatectomy - methods; Hepatocellular carcinoma; Hepatology; Humans; Learning algorithms; Liver - pathology; Liver - surgery; Liver cancer; Liver Neoplasms - mortality; Liver Neoplasms - pathology; Liver Neoplasms - surgery; Male; Medical prognosis; Metastases; Middle Aged; Neural networks; Prognosis; Risk Assessment - methods; Survival; Survival Analysis; Treatment Outcome
• ISSN: 0270-9139; 1527-3350; 1527-3350
• DOI: 10.1002/hep.31207

Background and Aims Standardized and robust risk‐stratification systems for patients with hepatocellular carcinoma (HCC) are required to improve therapeutic strategies and investigate the benefits of adjuvant systemic therapies after curative resection/ablation. Approach and Results In this study, we used two deep‐learning algorithms based on whole‐slide digitized histological slides (whole‐slide imaging; WSI) to build models for predicting survival of patients with HCC treated by surgical resection. Two independent series were investigated: a discovery set (Henri Mondor Hospital, n = 194) used to develop our algorithms and an independent validation set (The Cancer Genome Atlas [TCGA], n = 328). WSIs were first divided into small squares (“tiles”), and features were extracted with a pretrained convolutional neural network (preprocessing step). The first deep‐learning–based algorithm (“SCHMOWDER”) uses an attention mechanism on tumoral areas annotated by a pathologist whereas the second (“CHOWDER”) does not require human expertise. In the discovery set, c‐indices for survival prediction of SCHMOWDER and CHOWDER reached 0.78 and 0.75, respectively. Both models outperformed a composite score incorporating all baseline variables associated with survival. Prognostic value of the models was further validated in the TCGA data set, and, as observed in the discovery series, both models had a higher discriminatory power than a score combining all baseline variables associated with survival. Pathological review showed that the tumoral areas most predictive of poor survival were characterized by vascular spaces, the macrotrabecular architectural pattern, and a lack of immune infiltration. Conclusions This study shows that artificial intelligence can help refine the prediction of HCC prognosis. It highlights the importance of pathologist/machine interactions for the construction of deep‐learning algorithms that benefit from expert knowledge and allow a biological understanding of their output.