Involvement of FGFR4 Gene Variants on the Clinicopathological Severity in Urothelial Cell Carcinoma

• Published in: International journal of environmental research and public health Vol. 17; no. 1; p. 129
• Main Authors: Tsay, Ming-Dow, Hsieh, Ming-Ju, Lee, Chia-Yi, Wang, Shian-Shiang, Chen, Chuan-Shu, Hung, Sheng-Chun, Lin, Chia-Yen, Yang, Shun-Fa
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 23.12.2019; MDPI
• Subjects: Age; Aged; Alleles; Bladder; Bladder cancer; Carcinoma, Transitional Cell - genetics; Female; Gender; Gene expression; Genetic Predisposition to Disease; Genotype; Genotype & phenotype; Humans; Liver cancer; Lymphatic system; Male; Metastasis; Middle Aged; Odds Ratio; Polymorphism; Polymorphism, Single Nucleotide; Receptor, Fibroblast Growth Factor, Type 4 - genetics; Severity of Illness Index; Tobacco; Urinary Bladder Neoplasms - genetics; United States > US; fibroblast growth factor receptor 4; urothelial cell carcinoma; single-nucleotide polymorphism; tumor stage
• ISSN: 1660-4601; 1661-7827; 1660-4601
• DOI: 10.3390/ijerph17010129

Fibroblast growth factor receptor 4 (FGFR4) plays a prominent role in cell proliferation and cancer progression. This study explored the effect of FGFR4 single-nucleotide polymorphisms (SNPs) on the clinicopathological characteristics of urothelial cell carcinoma (UCC). This study was conducted to survey the possible correlation of the polymorphism of FGFR4 to the risk and clinicopathologic characteristics of UCC. Four loci of FGFR4 (rs2011077 T > C, rs351855 G > A, rs7708357 G>A, and rs1966265 A > G) were genotyped via the TaqMan allelic discrimination approach in 428 UCC cases and 856 controls. The results indicated that UCC subjects who carried the SNP rs2011077 TC+CC genotypes were significantly related to a higher tumor stage (odds ratio (OR): 1.751, 95% confidence interval (CI): 1.078–2.846), primary tumor size (OR: 1.637, 95% CI: 1.006–2.662), and histopathologic grading (OR: 1.919, 95% CI: 1.049–3.511). Moreover, the SNP rs1966265 AG+GG genotypes were prominently related to a higher tumor stage (OR: 1.769, 95% CI: 1.082–2.891), primary tumor size (OR: 1.654, 95% CI: 1.011–2.706), and histopathologic grading (OR: 2.006, 95% CI: 1.096–3.674) compared to individuals with AA homozygotes. In conclusion, our data reveal association of FGFR4 polymorphisms with UCC clinicopathologic characteristics. FGFR4 polymorphisms may serve as a marker or therapeutic target in UCC development.