Cyclic hardening in bundled actin networks

• Published in: Nature communications Vol. 1; no. 1; p. 134
• Main Authors: Schmoller, K. M., Fernández, P., Arevalo, R. C., Blair, D. L., Bausch, A. R.
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 2010; Nature Publishing Group
• Subjects: 631/57/2272/2274; 631/80/128/1276; 639/301/1023/303; Actins - chemistry; Actins - metabolism; Animals; Humanities and Social Sciences; Microscopy, Confocal; multidisciplinary; Muscle, Skeletal - metabolism; Rabbits; Rheology; Rubber; Science; Science (multidisciplinary); Strain
• ISSN: 2041-1723; 2041-1723
• DOI: 10.1038/ncomms1134

Nonlinear deformations can irreversibly alter the mechanical properties of materials. Most soft materials, such as rubber and living tissues, display pronounced softening when cyclically deformed. Here we show that, in contrast, reconstituted networks of crosslinked, bundled actin filaments harden when subject to cyclical shear. As a consequence, they exhibit a mechano-memory where a significant stress barrier is generated at the maximum of the cyclic shear strain. This unique response is crucially determined by the network architecture: at lower crosslinker concentrations networks do not harden, but soften showing the classic Mullins effect known from rubber-like materials. By simultaneously performing macrorheology and confocal microscopy, we show that cyclic shearing results in structural reorganization of the network constituents such that the maximum applied strain is encoded into the network architecture. Materials such as rubber tend to soften when cyclically deformed. Here, however, the authors find that bundled actin networks can show cyclic hardening and retain a memory of the maximum strain they have been subjected to.