Voltammetric nonenzymatic sensing of glucose by using a porous nanohybrid composed of CuS@SiO2 spheres and polypyrrole

• Published in: Mikrochimica acta (1966) Vol. 187; no. 5; p. 260
• Main Authors: Radhakrishnan, Sivaprakasam, Ganesan, Vinoth, Kim, Jinkwon
• Format: Journal Article
• Language: English
• Published: Vienna Springer Vienna 01.05.2020; Springer Nature B.V
• Subjects: Analytical Chemistry; Characterization and Evaluation of Materials; Chemistry; Chemistry and Materials Science; Copper sulfides; Electrodes; Glassy carbon; Glucose; Microengineering; Nanochemistry; Nanotechnology; Original Paper; Polypyrroles; Response time; Selectivity; Silicon dioxide; Silver chloride; Template method; Conducting polymers; Amperometric detection; Human blood serum; Hydrothermal method; One-pot preparation; Copper silicate; Metal sulfides
• ISSN: 0026-3672; 1436-5073; 1436-5073
• DOI: 10.1007/s00604-020-04227-5

Porous spheres of CuS@SiO 2 were obtained by deposition of CuS on silica spheres through a one-step chemical method. Subsequently, polypyrrole (PPy) was deposited on the CuS@SiO 2 spheres. The formation of the porous spheres was elucidated by control experiments and physical characterizations. The nanohybrid was placed on a glassy carbon electrode (GCE) surface where it displays good electrocatalytic activity in terms of glucose electrooxidation with an optimum at a working potential of 0.55 V (vs. Ag/AgCl) in 0.1 M NaOH solution. The PPy-CuS@SiO 2 achieves an extremely high sensitivity (505.3 μA mM −1  cm −2 ), wide linear range (10 μM–4.2 mM), low detection limit (1.0 μM), short response time (˂ 0.5 s), high selectivity, long-term durability, and reproducibility. The fabricated electrode based on PPy-CuS@SiO 2 was further used for the determination of glucose in blood sample with good recoveries. Graphical abstract Schematic representation of the method for fabrication of polypyrrole-coated porous CuS@SiO 2 sphere.