Influence of confounding factors on plasma Mid-Regional pro-Adrenomedullin and Mid-Regional pro-A-type Natriuretic Peptide concentrations in healthy individuals

• Published in: Biomarkers Vol. 16; no. 3; pp. 281 - 287
• Main Authors: Bhandari, Sanjay S., Davies, J. E., Struck, J., Ng, L. L.
• Format: Journal Article
• Language: English
• Published: England Informa Healthcare 01.05.2011; Taylor & Francis
• Subjects: Adrenomedullin - blood; Aged; Atrial Natriuretic Factor - blood; body mass index; Confounding Factors (Epidemiology); Female; heart failure; Humans; Male; mid-regional pro-A-type natriuretic peptide; Mid-regional pro-adrenomedullin; Middle Aged; Multivariate Analysis; Protein Precursors - blood; renal function
• ISSN: 1354-750X; 1366-5804; 1366-5804
• DOI: 10.3109/1354750X.2011.553750

Background: MRproADM and MRproANP can be used as diagnostic and prognostic markers in heart failure. Aim: The objective was to identify confounding factors for the interpretation of plasma MRproADM and MRproANP concentrations. Methods: A total of 518 healthy volunteers with a mean age of 60.84 ± 7.41 years were analyzed. We evaluated the influence of demographic factors, renal function and echocardiographic indices on the candidate peptides. Results: Multivariate analysis revealed that age (P < 0.001), BMI (P < 0.001) and eGFR (P < 0.001) were independent predictors for MRproADM concentrations in healthy subjects. The independent predictors for MRproANP were age (P < 0.001), female gender (P < 0.001), heart rate (P < 0.001) and eGFR (P = 0.039). Conclusion: The interpretation of both peptides is multifaceted due to confounders. Knowledge of these factors will further our understanding of how these peptides behave in health and in disease.