The interaction of anticancer therapies with tumor-associated macrophages

Macrophages are essential components of the inflammatory microenvironment of tumors. Conventional treatment modalities (chemotherapy and radiotherapy), targeted drugs, antiangiogenic agents, and immunotherapy, including checkpoint blockade, all profoundly influence or depend on the function of tumor...

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Bibliographic Details
Published inThe Journal of experimental medicine Vol. 212; no. 4; pp. 435 - 445
Main Authors Mantovani, Alberto, Allavena, Paola
Format Journal Article
LanguageEnglish
Published United States The Rockefeller University Press 06.04.2015
Subjects
Animals
Drug Resistance, Neoplasm - immunology
Humans
Immunotherapy - methods
Macrophages - immunology
Macrophages - pathology
Neoplasms - immunology
Neoplasms - pathology
Neoplasms - therapy
Review
Tumor Microenvironment - immunology
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ISSN0022-1007
1540-9538
1540-9538
DOI10.1084/jem.20150295

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Summary:Macrophages are essential components of the inflammatory microenvironment of tumors. Conventional treatment modalities (chemotherapy and radiotherapy), targeted drugs, antiangiogenic agents, and immunotherapy, including checkpoint blockade, all profoundly influence or depend on the function of tumor-associated macrophages (TAMs). Chemotherapy and radiotherapy can have dual influences on TAMs in that a misdirected macrophage-orchestrated tissue repair response can result in chemoresistance, but in other circumstances, TAMs are essential for effective therapy. A better understanding of the interaction of anticancer therapies with innate immunity, and TAMs in particular, may pave the way to better patient selection and innovative combinations of conventional approaches with immunotherapy.
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ISSN:0022-1007
1540-9538
1540-9538
DOI:10.1084/jem.20150295