Lactate infusion during euglycemia but not hypoglycemia reduces subsequent food intake in healthy men

• Published in: Appetite Vol. 58; no. 3; pp. 818 - 821
• Main Authors: Schultes, Bernd, Schmid, Sebastian M., Wilms, Britta, Jauch-Chara, Kamila, Oltmanns, Kerstin M., Hallschmid, Manfred
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.06.2012
• Subjects: Adult; Anorexia - etiology; Appetite - drug effects; body mass index; Eating - drug effects; Eating behavior; Energy Intake - drug effects; Fasting; Feeding Behavior - drug effects; Food intake; Glucose clamp technique; Glucose sensing; Humans; Hypoglycemia; insulin; Insulin - administration & dosage; intravenous injection; Lactate; lactates; Lactic Acid - pharmacology; Male; men; Reference Values; Young Adult; Lactate; Glucose clamp technique; Hypoglycemia; Food intake; Glucose sensing; Eating behavior
• ISSN: 0195-6663; 1095-8304; 1095-8304
• DOI: 10.1016/j.appet.2012.01.022

Considering that lactate is known to interact with central glucose-sensing networks, we tested whether hyperlactatemia affects food intake in humans. According to a balanced within-subject 2×2 design, 12 healthy, fasted men (age: 20–40years; BMI: 20–26kg/m2) were intravenously infused lactate and saline, respectively, for 105min during concomitant euglycemic and hypoglycemic, respectively, insulin infusion of 75min. Ten minutes after the simultaneous end of infusions, free-choice food intake was assessed at 10:25h. Lactate decreased food intake following euglycemia as compared to the other three conditions in which food intake did not differ. Results point to an anorexigenic effect of lactate under euglycemic conditions.