Perinatal BPA exposure demasculinizes males in measures of affect but has no effect on water maze learning in adulthood

• Published in: Hormones and behavior Vol. 61; no. 4; pp. 605 - 610
• Main Authors: Jones, Bryan A., Watson, Neil V.
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier Inc 01.04.2012; Elsevier; Elsevier BV
• Subjects: Affect - drug effects; Analysis of Variance; Androgen; Animal behavior; Animals; Anxiety - psychology; Behavior, Animal - drug effects; Behavioral psychophysiology; Benzhydryl Compounds; Biological and medical sciences; Bisphenol A; Depression - psychology; Dose–response; Elevated Plus Maze; Emotional responses; Endocrine Disruptors - pharmacology; Estrogen; Estrogens, Non-Steroidal - pharmacology; Female; Forced Swim Test; Fundamental and applied biological sciences. Psychology; Hormones; Hormones and behavior; Lactation - physiology; Male; Maze Learning - drug effects; Motor Activity - drug effects; Nonlinear Dynamics; Phenols - pharmacology; Pregnancy; Prenatal Exposure Delayed Effects - psychology; Psychology. Psychoanalysis. Psychiatry; Psychology. Psychophysiology; Rat; Rats; Rats, Long-Evans; Rodents; Sex Characteristics; Sex differences; Swimming - psychology; Water maze; Bisphenol A; Elevated Plus Maze; Dose–response; Androgen; Rat; Estrogen; Water maze; Forced Swim Test; Sex differences; Emotional responses; Affect affectivity; Sex; Male; Learning; Acquisition process; Adult; Dose-response; Human; Rodentia; Perinatal; Emotion emotionality; Exposure; Ovarian hormone; Vertebrata; Mammalia; Animal; Sex steroid hormone
• ISSN: 0018-506X; 1095-6867; 1095-6867
• DOI: 10.1016/j.yhbeh.2012.02.011

Bisphenol A (BPA) is an endocrine disrupting agent that can alter the normal gonadal steroid-sensitive sexual differentiation of the brain and behavior. While reproductive behavior and physiology are known to be altered by perinatal exposure to this compound, less is known about BPA's effects on sex differences in learning and measures of affect. In order to evaluate the effects of perinatal BPA treatment on learning and affect in adulthood, we exposed rats to one of five doses of BPA through gestation and lactation then examined adult behavior in the Morris Water Maze (MWM), the Elevated Plus Maze (EPM) and the Forced Swim Test (FST). No effect of BPA was observed in the MWM, but on both the EPM and FST, low doses (5μg/kg) of BPA eliminated sex differences found between controls; furthermore, a non-monotonic dose–response observed in previous studies was confirmed for these tasks. Overall, our study adds to the growing data suggesting that BPA interferes with the normal development of affective behaviors in a non-linear, dose-dependent manner. ► Bisphenol A exerts non-monotonic dose-related effects on emotional behavior. ► 5μg/kg daily BPA given perinatally abolishes the typical adult sex difference in the Elevated Plus Maze. ► 5μg/kg daily BPA given perinatally abolishes the normal adult sex difference in the Forced Swim Test. ► No dose of perinatal BPA altered adult water maze performance. ► BPA during the perinatal androgenic critical period thus altered adult emotional behavior.