Galectin-3 is associated with left ventricular reverse remodeling and outcome after percutaneous mitral valve repair

• Published in: International journal of cardiology Vol. 263; pp. 104 - 110
• Main Authors: Zuern, Christine S., Floss, Niklas, Mueller, Iris I., Eick, Christian, Duckheim, Martin, Patzelt, Johannes, Gawaz, Meinrad, May, Andreas E., Mueller, Karin A.L.
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 15.07.2018
• Subjects: Aged; Aged, 80 and over; Biomarker; Biomarkers - blood; Female; Follow-Up Studies; Galectin 3 - blood; Galectin-3; Humans; Male; Mitral Valve Insufficiency - blood; Mitral Valve Insufficiency - diagnostic imaging; Mitral Valve Insufficiency - surgery; Outcome; Percutaneous mitral valve repair; Prospective Studies; Reverse remodeling; Transcatheter Aortic Valve Replacement - trends; Treatment Outcome; Ventricular Remodeling - physiology; Biomarker; Galectin-3; Percutaneous mitral valve repair; Reverse remodeling; Outcome
• ISSN: 0167-5273; 1874-1754; 1874-1754
• DOI: 10.1016/j.ijcard.2018.04.025

Plasma Galectin-3 is a marker of myocardial inflammation and fibrosis, was associated with left ventricular (LV) reverse remodeling after conventional surgical mitral valve repair (MVR) and predicted clinical events in patients undergoing transcatheter aortic valve replacement (TAVR). We aimed to evaluate the association between pre-interventional Galectin-3 levels and (1) reverse LV remodeling and (2) major adverse cardiovascular events (MACE) in patients undergoing percutaneous MVR. Forty-four consecutive patients (median age 79 years, LV ejection fraction 39.5 ± 11.4%, 91% in NYHA functional class ≥III) with symptomatic moderate to severe mitral regurgitation undergoing percutaneous MVR were prospectively included. Plasma Galectin-3 levels were measured before the procedure. Echocardiographic and clinical assessment was performed at baseline and after 3 months. LV reverse remodeling was prospectively defined as a ≥10% increase in global longitudinal strain. MACE included death, myocardial infarction, heart failure related rehospitalization and stroke and was assessed after a mean follow-up time of 2 years. 72.7% of the patients showed LV reverse remodeling. Pre-interventional Galectin-3 < 10 ng/ml was an independent predictor of LV reverse remodeling (OR 10.3, 95% CI 1.2–83.9, p = 0.036). 25 patients (56.8%) experienced a MACE. Patients with Galectin-3 levels ≥ 10 ng/ml had significantly more MACE than patients with Galectin-3 levels < 10 ng/ml (100% vs. 45.5%, p = 0.003). Diabetes independently predicted MACE (HR 3.1, 95% CI 1.0–9.4, p = 0.049); Galectin-3 ≥ 10 ng/ml was of borderline significance (HR 2.2, 95% CI 0.9–5.4, p = 0.088). Pre-interventional plasma Galectin-3 levels are associated with LV reverse remodeling and with clinical outcome after percutaneous MVR.