Population-based study of DNA image cytometry as screening method for esophageal cancer

• Published in: World journal of gastroenterology : WJG Vol. 18; no. 4; pp. 375 - 382
• Main Author: Zhao, Lin
• Format: Journal Article
• Language: English
• Published: United States Baishideng Publishing Group Co., Limited 28.01.2012
• Subjects: Adult; Aged; Brief; China; Cytodiagnosis - methods; DNA; Esophageal Neoplasms - diagnosis; Esophageal Neoplasms - genetics; Esophageal Neoplasms - pathology; Female; Humans; Image Cytometry - methods; Male; Mass Screening - methods; Middle Aged; Precancerous Conditions - diagnosis; Precancerous Conditions - genetics; Precancerous Conditions - pathology; ROC Curve; Sensitivity and Specificity; 人口; 初筛方法; 图像分析技术; 灵敏度; 筛查; 细胞学; 食管癌; China; Precancerous lesions; Screening; Aneuploidy; DNA image cytometry; Esophageal cancer
• ISSN: 1007-9327; 2219-2840; 2219-2840
• DOI: 10.3748/wjg.v18.i4.375

AIM：To explore the DNA image cytometry （DNA-ICM） technique as a primary screening method for esopha-geal squamous precancerous lesions.METHODS：This study was designed as a population-based screening study.A total of 582 local residents aged 40 years-69 years were recruited from Linzhou in Henan and Feicheng in Shandong.However,only 452 subjects had results of liquid-based cytology,DNA-ICM and pathology.The sensitivity and specificity of DNA-ICM were calculated and compared with liquid-based cytology in moderate dysplasia or worse.RESULTS：Sensitivities of DNA-ICM ranging from at least 1 to 4 aneuploid cells were 90.91%,86.36%,79.55% and 77.27%,respectively,which were better than that of liquid-based cytology （75%）.Specifici-ties of DNA-ICM were 70.83%,84.07%,92.65% and 96.81%,but the specificity of liquid-based cytology was 91.91%.The sensitivity and specificity of a combination of liquid-based cytology and DNA-ICM were 84.09% and 85.78%,respectively.CONCLUSION：It is possible to use DNA-ICM tech-nique as a primary screening method for esophageal squamous precancerous lesions.