Stretch-reflex threshold modulation during active elbow movements in post-stroke survivors with spasticity

• Published in: Clinical neurophysiology Vol. 128; no. 10; pp. 1891 - 1897
• Main Authors: Turpin, Nicolas A., Feldman, Anatol G., Levin, Mindy F.
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.10.2017
• Subjects: Adult; Aged; Elbow Joint - physiology; Female; Humans; Male; Middle Aged; Movement - physiology; Muscle spasticity; Muscle Spasticity - diagnosis; Muscle Spasticity - etiology; Muscle Spasticity - physiopathology; Reflex, Stretch - physiology; Rehabilitation; Sensory Thresholds - physiology; Stretch reflex; Stroke; Stroke - complications; Stroke - diagnosis; Voluntary movement; Stretch reflex; Stroke; Rehabilitation; Voluntary movement; Muscle spasticity
• ISSN: 1388-2457; 1872-8952; 1872-8952
• DOI: 10.1016/j.clinph.2017.07.411

•Tonic stretch-reflex thresholds in post-stroke spasticity occurred within the joint range at rest.•Threshold modulation during active movements was related to clinical spasticity and motor impairment.•Characteristics of threshold modulation provide information about post-stroke sensorimotor deficits. Voluntary movements post-stroke are affected by abnormal muscle activation due to exaggerated stretch reflexes (SRs). We examined the ability of post-stroke subjects to regulate SRs in spastic muscles. Elbow flexor and extensor EMGs and joint angle were recorded in 13 subjects with chronic post-stroke spasticity. Muscles were either stretched passively (relaxed arm) or actively (antagonist contraction) at different velocities. Velocity-dependent SR thresholds were defined as angles where stretched muscle EMG exceeded 3SDs of baseline. Sensitivity of SRs to stretch velocity was defined as µ. The regression through thresholds was interpolated to zero velocity to obtain the tonic SR threshold (TSRT) angle. Compared to passive stretches, TSRTs during active motion occurred at longer muscle lengths (i.e., increased in flexors and decreased in extensors by 10–40°). Values of μ increased by 1.5–4.0. Changes in flexor TSRTs during active compared to passive stretches were correlated with clinical spasticity (r=−0.68) and arm motor impairment (r=0.81). Spasticity thresholds measured at rest were modulated during active movement. Arm motor impairments were related to the ability to modulate SR thresholds between the two states rather than to passive-state values. Relationship between spasticity and movement disorders may be explained by deficits in SR threshold range of regulation and modifiability, representing a measure of stroke-related sensorimotor deficits.