Dose‐response relationship between late‐life physical activity and incident dementia: A pooled analysis of 10 cohort studies of memory in an international consortium

Introduction Though consistent evidence suggests that physical activity may delay dementia onset, the duration and amount of activity required remains unclear. Methods We harmonized longitudinal data of 11,988 participants from 10 cohorts in eight countries to examine the dose‐response relationship...

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Published in	Alzheimer's & dementia Vol. 19; no. 1; pp. 107 - 122
Main Authors	Wu, Wanqing, Ding, Ding, Zhao, Qianhua, Xiao, Zhenxu, Luo, Jianfeng, Ganguli, Mary, Hughes, Tiffany F., Jacobsen, Erin, Haan, Mary N., Dang, Kristine, Lima‐Costa, Maria Fernanda, Blay, Sergio Luis, Castro‐Costa, Erico, Ng, Tze Pin, Gwee, Xinyi, Gao, Qi, Gureje, Oye, Ojagbemi, Akin, Bello, Toyin, Shahar, Suzana, Ludin, Arimi Fitri Mat, Rivan, Nurul Fatin Malek, Scarmeas, Nikolaos, Anastasiou, Costas A., Yannakoulia, Mary, Brodaty, Henry, Crawford, John D., Lipton, Richard B., Derby, Carol A., Katz, Mindy J., Lipnicki, Darren M., Sachdev, Perminder S.
Format	Journal Article
Language	English
Published	United States 01.01.2023
Subjects	Aged cohort Cohort Studies dementia Dementia - epidemiology dose‐response Humans physical activity pooled analysis population‐based Proportional Hazards Models Risk Factors dose-response cohort dementia pooled analysis population-based physical activity
Online Access	Get full text
ISSN	1552-5260 1552-5279 1552-5279
DOI	10.1002/alz.12628

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Abstract	Introduction Though consistent evidence suggests that physical activity may delay dementia onset, the duration and amount of activity required remains unclear. Methods We harmonized longitudinal data of 11,988 participants from 10 cohorts in eight countries to examine the dose‐response relationship between late‐life physical activity and incident dementia among older adults. Results Using no physical activity as a reference, dementia risk decreased with duration of physical activity up to 3.1 to 6.0 hours/week (hazard ratio [HR] 0.88, 95% confidence interval [CI] 0.67 to 1.15 for 0.1 to 3.0 hours/week; HR 0.68, 95% CI 0.52 to 0.89 for 3.1 to 6.0 hours/week), but plateaued with higher duration. For the amount of physical activity, a similar pattern of dose‐response curve was observed, with an inflection point of 9.1 to 18.0 metabolic equivalent value (MET)‐hours/week (HR 0.92, 95% CI 0.70 to 1.22 for 0.1 to 9.0 MET‐hours/week; HR 0.70, 95% CI 0.53 to 0.93 for 9.1 to 18.0 MET‐hours/week). Discussion This cross‐national analysis suggests that performing 3.1 to 6.0 hours of physical activity and expending 9.1 to 18.0/MET‐hours of energy per week may reduce dementia risk.
AbstractList	Introduction Though consistent evidence suggests that physical activity may delay dementia onset, the duration and amount of activity required remains unclear. Methods We harmonized longitudinal data of 11,988 participants from 10 cohorts in eight countries to examine the dose‐response relationship between late‐life physical activity and incident dementia among older adults. Results Using no physical activity as a reference, dementia risk decreased with duration of physical activity up to 3.1 to 6.0 hours/week (hazard ratio [HR] 0.88, 95% confidence interval [CI] 0.67 to 1.15 for 0.1 to 3.0 hours/week; HR 0.68, 95% CI 0.52 to 0.89 for 3.1 to 6.0 hours/week), but plateaued with higher duration. For the amount of physical activity, a similar pattern of dose‐response curve was observed, with an inflection point of 9.1 to 18.0 metabolic equivalent value (MET)‐hours/week (HR 0.92, 95% CI 0.70 to 1.22 for 0.1 to 9.0 MET‐hours/week; HR 0.70, 95% CI 0.53 to 0.93 for 9.1 to 18.0 MET‐hours/week). Discussion This cross‐national analysis suggests that performing 3.1 to 6.0 hours of physical activity and expending 9.1 to 18.0/MET‐hours of energy per week may reduce dementia risk. Though consistent evidence suggests that physical activity may delay dementia onset, the duration and amount of activity required remains unclear. We harmonized longitudinal data of 11,988 participants from 10 cohorts in eight countries to examine the dose-response relationship between late-life physical activity and incident dementia among older adults. Using no physical activity as a reference, dementia risk decreased with duration of physical activity up to 3.1 to 6.0 hours/week (hazard ratio [HR] 0.88, 95% confidence interval [CI] 0.67 to 1.15 for 0.1 to 3.0 hours/week; HR 0.68, 95% CI 0.52 to 0.89 for 3.1 to 6.0 hours/week), but plateaued with higher duration. For the amount of physical activity, a similar pattern of dose-response curve was observed, with an inflection point of 9.1 to 18.0 metabolic equivalent value (MET)-hours/week (HR 0.92, 95% CI 0.70 to 1.22 for 0.1 to 9.0 MET-hours/week; HR 0.70, 95% CI 0.53 to 0.93 for 9.1 to 18.0 MET-hours/week). This cross-national analysis suggests that performing 3.1 to 6.0 hours of physical activity and expending 9.1 to 18.0/MET-hours of energy per week may reduce dementia risk. Though consistent evidence suggests that physical activity may delay dementia onset, the duration and amount of activity required remains unclear.INTRODUCTIONThough consistent evidence suggests that physical activity may delay dementia onset, the duration and amount of activity required remains unclear.We harmonized longitudinal data of 11,988 participants from 10 cohorts in eight countries to examine the dose-response relationship between late-life physical activity and incident dementia among older adults.METHODSWe harmonized longitudinal data of 11,988 participants from 10 cohorts in eight countries to examine the dose-response relationship between late-life physical activity and incident dementia among older adults.Using no physical activity as a reference, dementia risk decreased with duration of physical activity up to 3.1 to 6.0 hours/week (hazard ratio [HR] 0.88, 95% confidence interval [CI] 0.67 to 1.15 for 0.1 to 3.0 hours/week; HR 0.68, 95% CI 0.52 to 0.89 for 3.1 to 6.0 hours/week), but plateaued with higher duration. For the amount of physical activity, a similar pattern of dose-response curve was observed, with an inflection point of 9.1 to 18.0 metabolic equivalent value (MET)-hours/week (HR 0.92, 95% CI 0.70 to 1.22 for 0.1 to 9.0 MET-hours/week; HR 0.70, 95% CI 0.53 to 0.93 for 9.1 to 18.0 MET-hours/week).RESULTSUsing no physical activity as a reference, dementia risk decreased with duration of physical activity up to 3.1 to 6.0 hours/week (hazard ratio [HR] 0.88, 95% confidence interval [CI] 0.67 to 1.15 for 0.1 to 3.0 hours/week; HR 0.68, 95% CI 0.52 to 0.89 for 3.1 to 6.0 hours/week), but plateaued with higher duration. For the amount of physical activity, a similar pattern of dose-response curve was observed, with an inflection point of 9.1 to 18.0 metabolic equivalent value (MET)-hours/week (HR 0.92, 95% CI 0.70 to 1.22 for 0.1 to 9.0 MET-hours/week; HR 0.70, 95% CI 0.53 to 0.93 for 9.1 to 18.0 MET-hours/week).This cross-national analysis suggests that performing 3.1 to 6.0 hours of physical activity and expending 9.1 to 18.0/MET-hours of energy per week may reduce dementia risk.DISCUSSIONThis cross-national analysis suggests that performing 3.1 to 6.0 hours of physical activity and expending 9.1 to 18.0/MET-hours of energy per week may reduce dementia risk.
Author	Yannakoulia, Mary Hughes, Tiffany F. Bello, Toyin Lima‐Costa, Maria Fernanda Blay, Sergio Luis Zhao, Qianhua Ojagbemi, Akin Derby, Carol A. Katz, Mindy J. Gureje, Oye Jacobsen, Erin Sachdev, Perminder S. Brodaty, Henry Wu, Wanqing Castro‐Costa, Erico Ng, Tze Pin Ding, Ding Anastasiou, Costas A. Ludin, Arimi Fitri Mat Ganguli, Mary Haan, Mary N. Luo, Jianfeng Dang, Kristine Lipnicki, Darren M. Gao, Qi Xiao, Zhenxu Shahar, Suzana Lipton, Richard B. Gwee, Xinyi Scarmeas, Nikolaos Rivan, Nurul Fatin Malek Crawford, John D.
AuthorAffiliation	8 Department of Psychological Medicine, National University of Singapore, Singapore, Singapore 3 Department of Psychiatry, University of Pittsburgh, Pittsburgh, USA 6 Center for Studies in Public Health and Aging’ René Rachou Research Center, Oswaldo Cruz Foundation, Belo Horizonte, Brazil 15 Department of Nutrition and Dietetics, Harokopio University, Athens, Greece 2 Department of Biostatistics, School of Public Health, Fudan University, Shanghai, China 4 Department of Health Professions, Youngstown State University, OH, USA 5 Department of Epidemiology and Biostatistics, University of California at San Francisco, San Francisco, USA 12 Biomedical Science Program, Centre for Healthy Aging, University Kebangsaan Malaysia, Kuala Lumpur, Malaysia 9 National Public Health and Epidemiology Unit, National Centre for Infectious Diseases, Singapore, Singapore 16 Centre for Healthy Brain Ageing, University of New South Wales, Sydney, Australia 13 Nutritional Sciences Program, Centre for Healthy Aging, U
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Notes	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 AUTHOR CONTRIBUTION DD, PSS, MG, MNH, MFLC, TPN, OG, SS, NS, HB, RBL were responsible for study conceptualization and design. WW, ZX, EJ, TPN, XG, QG, OG, AFML, NFMR, NS, CAA, MY, RBL, MJK were responsible for data collection. WW, ZX, TPN, XG, QG, NS, JDC, MJK, DML were responsible for data curation. WW and DD were responsible for data validation. WW, TPN, XG, QG, SS, MJK, DML were responsible for project administration. DD, QZ, TPN, OG, NS, PSS were responsible for funding acquisition. WW, DD, JL were responsible for data analysis. WW and DD were responsible for original draft. All authors contributed to data interpretation, reviewed, and approved the final draft of the paper. All authors had full access to all the data in the study and had final responsibility for the decision to submit for publication.
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Snippet	Introduction Though consistent evidence suggests that physical activity may delay dementia onset, the duration and amount of activity required remains unclear.... Though consistent evidence suggests that physical activity may delay dementia onset, the duration and amount of activity required remains unclear. We... Though consistent evidence suggests that physical activity may delay dementia onset, the duration and amount of activity required remains...
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SubjectTerms	Aged cohort Cohort Studies dementia Dementia - epidemiology dose‐response Humans physical activity pooled analysis population‐based Proportional Hazards Models Risk Factors
Title	Dose‐response relationship between late‐life physical activity and incident dementia: A pooled analysis of 10 cohort studies of memory in an international consortium
URI	https://onlinelibrary.wiley.com/doi/abs/10.1002%2Falz.12628 https://www.ncbi.nlm.nih.gov/pubmed/35290713 https://www.proquest.com/docview/2640047611 https://pubmed.ncbi.nlm.nih.gov/PMC9652610
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