Dose‐response relationship between late‐life physical activity and incident dementia: A pooled analysis of 10 cohort studies of memory in an international consortium

Introduction Though consistent evidence suggests that physical activity may delay dementia onset, the duration and amount of activity required remains unclear. Methods We harmonized longitudinal data of 11,988 participants from 10 cohorts in eight countries to examine the dose‐response relationship...

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Published inAlzheimer's & dementia Vol. 19; no. 1; pp. 107 - 122
Main Authors Wu, Wanqing, Ding, Ding, Zhao, Qianhua, Xiao, Zhenxu, Luo, Jianfeng, Ganguli, Mary, Hughes, Tiffany F., Jacobsen, Erin, Haan, Mary N., Dang, Kristine, Lima‐Costa, Maria Fernanda, Blay, Sergio Luis, Castro‐Costa, Erico, Ng, Tze Pin, Gwee, Xinyi, Gao, Qi, Gureje, Oye, Ojagbemi, Akin, Bello, Toyin, Shahar, Suzana, Ludin, Arimi Fitri Mat, Rivan, Nurul Fatin Malek, Scarmeas, Nikolaos, Anastasiou, Costas A., Yannakoulia, Mary, Brodaty, Henry, Crawford, John D., Lipton, Richard B., Derby, Carol A., Katz, Mindy J., Lipnicki, Darren M., Sachdev, Perminder S.
Format Journal Article
LanguageEnglish
Published United States 01.01.2023
Subjects
Aged
cohort
Cohort Studies
dementia
Dementia - epidemiology
dose‐response
Humans
physical activity
pooled analysis
population‐based
Proportional Hazards Models
Risk Factors
dose-response
cohort
dementia
pooled analysis
population-based
physical activity
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ISSN1552-5260
1552-5279
1552-5279
DOI10.1002/alz.12628

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Summary:Introduction Though consistent evidence suggests that physical activity may delay dementia onset, the duration and amount of activity required remains unclear. Methods We harmonized longitudinal data of 11,988 participants from 10 cohorts in eight countries to examine the dose‐response relationship between late‐life physical activity and incident dementia among older adults. Results Using no physical activity as a reference, dementia risk decreased with duration of physical activity up to 3.1 to 6.0 hours/week (hazard ratio [HR] 0.88, 95% confidence interval [CI] 0.67 to 1.15 for 0.1 to 3.0 hours/week; HR 0.68, 95% CI 0.52 to 0.89 for 3.1 to 6.0 hours/week), but plateaued with higher duration. For the amount of physical activity, a similar pattern of dose‐response curve was observed, with an inflection point of 9.1 to 18.0 metabolic equivalent value (MET)‐hours/week (HR 0.92, 95% CI 0.70 to 1.22 for 0.1 to 9.0 MET‐hours/week; HR 0.70, 95% CI 0.53 to 0.93 for 9.1 to 18.0 MET‐hours/week). Discussion This cross‐national analysis suggests that performing 3.1 to 6.0 hours of physical activity and expending 9.1 to 18.0/MET‐hours of energy per week may reduce dementia risk.
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AUTHOR CONTRIBUTION
DD, PSS, MG, MNH, MFLC, TPN, OG, SS, NS, HB, RBL were responsible for study conceptualization and design. WW, ZX, EJ, TPN, XG, QG, OG, AFML, NFMR, NS, CAA, MY, RBL, MJK were responsible for data collection. WW, ZX, TPN, XG, QG, NS, JDC, MJK, DML were responsible for data curation. WW and DD were responsible for data validation. WW, TPN, XG, QG, SS, MJK, DML were responsible for project administration. DD, QZ, TPN, OG, NS, PSS were responsible for funding acquisition. WW, DD, JL were responsible for data analysis. WW and DD were responsible for original draft. All authors contributed to data interpretation, reviewed, and approved the final draft of the paper. All authors had full access to all the data in the study and had final responsibility for the decision to submit for publication.
ISSN:1552-5260
1552-5279
1552-5279
DOI:10.1002/alz.12628