Strongyloides stercoralis in Alcoholic Patients: Implications of Alcohol Intake in the Frequency of Infection and Parasite Load

• Published in: Pathogens (Basel) Vol. 9; no. 6; p. 422
• Main Authors: de Souza, Joelma N., Oliveira, Cíntia de L., Araújo, Wéslei A. C., Souza, Alex B. S., Silva, Mônica L. S., da Cruz, Irlana D. R., Sampaio, Larissa M., dos Santos, Juliane S. B., Teixeira, Márcia C. A., Soares, Neci M.
• Format: Journal Article
• Language: English
• Published: Basel MDPI AG 28.05.2020; MDPI
• Subjects: agar; alcohol abuse; alcohol drinking; Alcohol use; alcoholic individuals; Alcoholics; Alcoholism; Alcohols; Chronic infection; Diagnostic systems; diagnostic techniques; disease severity; Evaluation; Feces; frequency; infection; Infections; Laboratories; Larvae; lead; Methods; parasite load; Parasites; pathogens; patients; population; prevalence; Questionnaires; Sedimentation; Sedimentation & deposition; Sensitivity analysis; Socioeconomic factors; Standard deviation; Strongyloides stercoralis; Studies; Brazil; United States > US
• ISSN: 2076-0817; 2076-0817
• DOI: 10.3390/pathogens9060422

Strongyloides stercoralis infection in immunocompromised subjects, including chronic alcoholics, can lead to a severe disease. Moreover, its prevalence in alcoholic patients seems to be higher than that in the general population. The aims of this study were to evaluate the frequency of S. stercoralis infection in alcoholic patients and to investigate the influence of alcohol intake on the parasite load, as well as to evaluate the sensitivity of three different parasitological methods according to the larval output. Fecal samples of 1290 chronic alcoholic patients were examined by spontaneous sedimentation, Baermann–Moraes, and agar plate culture (APC) methods. S. stercoralis was the most frequent parasite found (14.5%; n = 187). Alcoholic individuals infected with Strongyloides stercoralis had a higher daily consumption of alcohol than those who were not infected, 528.6 and 403.0 g/day, respectively (p < 0.05). In addition, individuals with higher alcohol intake presented an increase in parasite load. The S. stercoralis diagnostic method with the highest sensitivity was APC, 97.9% (183/187). In conclusion, S. stercoralis seems to be the most frequent parasite found in alcoholic individuals from endemic areas and alcohol intake is positively associated with S. stercoralis larvae output. In addition, this study confirms that APC is the most sensitive parasitological method used for Strongyloides diagnosis.