Imaging Characteristics of the Proximal Lateral Collateral Ligament of the Knee: Findings on Ultrasound and MRI With Histologic Correlation

• Published in: Journal of ultrasound in medicine Vol. 41; no. 4; pp. 827 - 834
• Main Authors: Falkowski, Anna L., Jacobson, Jon A., Gandikota, Girish, Lucas, David R., Magerkurth, Olaf, Zaottini, Federico
• Format: Journal Article
• Language: English
• Published: Hoboken, USA John Wiley & Sons, Inc 01.04.2022
• Subjects: Adult; Collateral Ligaments; diagnostic imaging; Female; Humans; knee; Knee Joint - pathology; Lateral Ligament, Ankle - diagnostic imaging; ligaments; Magnetic Resonance Imaging; Male; Middle Aged; Original Research; Prospective Studies; Reproducibility of Results; Ultrasonography; knee; magnetic resonance imaging; ultrasonography; diagnostic imaging; ligaments
• ISSN: 0278-4297; 1550-9613; 1550-9613
• DOI: 10.1002/jum.15761

Objectives Determine prevalence of increased signal intensity of the lateral collateral ligament (LCL) of the knee on MRI and decreased echogenicity on ultrasound, and compare with cadaveric histologic evaluation. Methods After IRB approval of this prospective study with informed consent, patients having knee MRI were additionally evaluated with ultrasound. Signal intensities of LCL on MRI (low, intermediate, high), echogenicity at ultrasound (hyperechoic, hypoechoic, anechoic), and extent of findings were assessed. Descriptive statistics, Wilcoxon signed ranked test, and intraclass correlation coefficient (ICC) were calculated. Two cadaveric knees were imaged with MRI and ultrasound, including histologic LCL evaluation. Results Seventy‐three subjects were included (39 males, 34 females; mean age 48 ± 14 years) with 77 knee examinations. On MRI, low, intermediate, and high signals were present in 21% (16/77), 75% (58/77), and 4% (3/77), respectively. On ultrasound, echogenicity was assessed as hyperechoic, hypoechoic, and anechoic in 62% (48/77), 38% (29/77), and 0% (0/77), respectively. Mean length of increased signal was 8.6 mm (±4.9) on MRI, and 6.5 mm (±4.8) on ultrasound. The ICC showed a good to excellent intermodality reliability (0.735–0.899) without statistically significant difference for interreader measurements (P = .163–.795). Histology evaluation showed transition of ligament fibers to fibrocartilage at its insertion with increased connective tissue mucin corresponding to MRI and ultrasound findings. Conclusions Increased signal intensity of the proximal LCL on ultrasound and MRI is common and corresponds to normal connective tissue mucin.