Serum Bisphenol A Concentration and Premature Thelarche in Female Infants Aged 4-month to 2-year

• Published in: Indian journal of pediatrics Vol. 82; no. 3; pp. 221 - 224
• Main Authors: Chen, Lian-hui, Shi, Jian-rong, Fang, Yan-lan, Liang, Li, Chen, Wan-qin, Chen, Xiao-zhen
• Format: Journal Article
• Language: English
• Published: India Springer India 01.03.2015
• Subjects: Benzhydryl Compounds - blood; Breast - growth & development; Breast - pathology; China; Chromatography, Liquid - methods; Female; Gynecology; Humans; Infant; Medicine; Medicine & Public Health; Original Article; Pediatrics; Phenols - blood; Puberty, Precocious - blood; Puberty, Precocious - diagnosis; Puberty, Precocious - etiology; Statistics as Topic; Premature thelarche; Bisphenol A; Infants
• ISSN: 0019-5456; 0973-7693; 0973-7693
• DOI: 10.1007/s12098-014-1548-7

Objectives To estimate the association between serum bisphenol A and premature thelarche in female infants aged 4-mo to 2-y. Methods A total of 251 female infants (aged 4 mo to 2 y) with premature thelarche and 33 healthy age-matched control subjects were analyzed. All participants underwent physical examination and serum bisphenol A was measured by ultra-performance liquid chromatography tandem mass spectrometry. Results Serum bisphenol A concentration in the premature thelarche group (3.48 ng/ml, 95%CI: 0.09-140.26) was significantly higher than that in the control group (1.70 ng/ml, 95%CI: 0.06–51.78) ( p  = 0.039). There was no correlation between age and serum bisphenol A (BPA) level. Univariate logistic regression analysis showed that serum BPA concentration positively associated with premature thelarche, and the effect of BPA fell down as the age grew. Conclusions This hospital-based study implied that there is an association between serum BPA concentrations and premature thelarche. Additionally, serum BPA levels were markedly higher in infants aged 4-mo to 2-y-old, raising a concern for public health authorities.