Human induced pluripotent stem cells generated from epilepsy patients for use as in vitro models for drug screening

In this paper, we describe the generation and validation of human induced pluripotent stem cell (hiPSC) lines from peripheral blood mononuclear cells (PBMCs) from 6 epilepsy patients using a non-integrative Sendai virus vector. These human cellular models will enable patient-specific drug screening...

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Bibliographic Details
Published inStem cell research Vol. 60; p. 102673
Main Authors Hunter, Zoe L., Leeson, Hannah C., Shaker, Mohammed R., Wolvetang, Ernst J., Vadlamudi, Lata
Format Journal Article
LanguageEnglish
Published England Elsevier B.V 01.04.2022
Elsevier
Subjects
Cell Differentiation
Cellular Reprogramming
Drug Evaluation, Preclinical
Epilepsy
Humans
Induced Pluripotent Stem Cells - metabolism
Leukocytes, Mononuclear
Sendai virus
Online AccessGet full text
ISSN1873-5061
1876-7753
1876-7753
DOI10.1016/j.scr.2022.102673

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Summary:In this paper, we describe the generation and validation of human induced pluripotent stem cell (hiPSC) lines from peripheral blood mononuclear cells (PBMCs) from 6 epilepsy patients using a non-integrative Sendai virus vector. These human cellular models will enable patient-specific drug screening to improve outcomes for individuals with this disorder.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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ISSN:1873-5061
1876-7753
1876-7753
DOI:10.1016/j.scr.2022.102673