Bone Turnover and Bone Mineral Density Are Independently Related to Selenium Status in Healthy Euthyroid Postmenopausal Women

• Published in: The journal of clinical endocrinology and metabolism Vol. 97; no. 11; pp. 4061 - 4070
• Main Authors: Hoeg, Antonia, Gogakos, Apostolos, Murphy, Elaine, Mueller, Sandra, Köhrle, Josef, Reid, David M., Glüer, Claus C., Felsenberg, Dieter, Roux, Christian, Eastell, Richard, Schomburg, Lutz, Williams, Graham R.
• Format: Journal Article
• Language: English
• Published: Bethesda, MD Oxford University Press 01.11.2012; Endocrine Society
• Subjects: Aged; Aged, 80 and over; Biological and medical sciences; Bone density; Bone Density - physiology; Bone growth; Bone mineral density; Bone resorption; Bone turnover; Collagen; Drug metabolism; Endocrinopathies; Feeding. Feeding behavior; Female; Fractures; Fractures, Bone - blood; Fractures, Bone - physiopathology; Fundamental and applied biological sciences. Psychology; Hip; Humans; Medical sciences; Middle Aged; Osteocalcin; Osteogenesis; Osteoporosis; Population studies; Post-menopause; Postmenopause - blood; Postmenopause - physiology; Procollagen; Prospective Studies; Selenium; Selenium - blood; Selenoprotein P - blood; Spine (lumbar); Thyroid diseases; Thyroid gland; Thyroid Hormones - blood; Thyroid-stimulating hormone; Thyroxine; Triiodothyronine; Vertebrae; Vertebrates: anatomy and physiology, studies on body, several organs or systems; Vertebrates: endocrinology; Women's Health; Human; Obesity; Nutrition; Nutrition disorder; Metabolic diseases; Turnover; Postmenopause; Female; Bone mineral density; Selenium; Woman; Endocrinology; Nutritional status
• ISSN: 0021-972X; 1945-7197; 1945-7197
• DOI: 10.1210/jc.2012-2121

Context:Selenium status may have direct effects on bone and indirect effects through changes in thyroid hormone sensitivity.Objective:We hypothesized that variation in selenium status in healthy euthyroid postmenopausal women is associated with differences in bone turnover, bone mineral density (BMD) and fracture susceptibility.Design:The Osteoporosis and Ultrasound Study (OPUS) is a 6-yr prospective study of fracture-related factors.Setting:The study was comprised of a population-based cohort from five European cities.Participants:A total of 2374 postmenopausal women participated. Subjects with thyroid disease and nonthyroidal illness and those receiving drugs affecting thyroid status or bone metabolism were excluded, leaving a study population of 1144.Interventions:There were no interventions.Main Outcome Measures:We measured selenium (micrograms per liter); selenoprotein P (milligrams per liter); free T4 (picomoles per liter); free T3 (picomoles per liter); TSH (milliunits per liter); bone turnover markers; BMD; and vertebral, hip, and nonvertebral fractures.Results:Higher selenium levels were associated with higher hip BMD at study entry (β = 0.072, P = 0.004) and lower levels of bone formation (osteocalcin: β = −0.101, P < 0.001; procollagen type 1 N-terminal propeptide: β = −0.074, P = 0.013) and resorption markers (C-telopeptide of type 1 collagen: β = −0.058, P = 0.050; N-telopeptide of type 1 collagen: β = −0.095, P = 0.002). Higher selenoprotein P was associated with higher hip (β = 0.113, P < 0.001) and lumbar spine BMD (β = 0.088, P = 0.003) at study entry, higher hip BMD after the 6-yr follow-up (β = 0.106, P = 0.001) and lower osteocalcin (β = −0.077, P = 0.009), C-telopeptide of type 1 collagen (β = −0.075, P = 0.012), and N-telopeptide of type 1 collagen (β = −0.110, P < 0.001).Conclusion:Selenium status is inversely related to bone turnover and positively correlated with BMD in healthy euthyroid postmenopausal women independent of thyroid status.