Short-term effects of electronic and tobacco cigarettes on exhaled nitric oxide

The objective of this study was to compare the short-term respiratory effects due to the inhalation of electronic and conventional tobacco cigarette-generated mainstream aerosols through the measurement of the exhaled nitric oxide (eNO). To this purpose, twenty-five smokers were asked to smoke a con...

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Published inToxicology and applied pharmacology Vol. 278; no. 1; pp. 9 - 15
Main Authors Marini, Sara, Buonanno, Giorgio, Stabile, Luca, Ficco, Giorgio
Format Journal Article
LanguageEnglish
Published Amsterdam Elsevier Inc 01.07.2014
Elsevier
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ISSN0041-008X
1096-0333
1096-0333
DOI10.1016/j.taap.2014.04.004

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Summary:The objective of this study was to compare the short-term respiratory effects due to the inhalation of electronic and conventional tobacco cigarette-generated mainstream aerosols through the measurement of the exhaled nitric oxide (eNO). To this purpose, twenty-five smokers were asked to smoke a conventional cigarette and to vape an electronic cigarette (with and without nicotine), and an electronic cigarette without liquid (control session). Electronic and tobacco cigarette mainstream aerosols were characterized in terms of total particle number concentrations and size distributions. On the basis of the measured total particle number concentrations and size distributions, the average particle doses deposited in alveolar and tracheobronchial regions of the lungs for a single 2-s puff were also estimated considering a subject performing resting (sitting) activity. Total particle number concentrations in the mainstream resulted equal to 3.5±0.4×109, 5.1±0.1×109, and 3.1±0.6×109 part. cm−3 for electronic cigarettes without nicotine, with nicotine, and for conventional cigarettes, respectively. The corresponding alveolar doses for a resting subject were estimated equal to 3.8×1010, 5.2×1010 and 2.3×1010 particles. The mean eNO variations measured after each smoking/vaping session were equal to 3.2ppb, 2.7ppb and 2.8ppb for electronic cigarettes without nicotine, with nicotine, and for conventional cigarettes, respectively; whereas, negligible eNO changes were measured in the control session. Statistical tests performed on eNO data showed statistically significant differences between smoking/vaping sessions and the control session, thus confirming a similar effect on human airways whatever the cigarette smoked/vaped, the nicotine content, and the particle dose received. •Electronic cigarettes (with and without nicotine) mainstream aerosols were analyzed;•Particle number concentrations and size distributions were measured;•Nitric oxide exhaled by smokers before and after smoking/vaping was evaluated;•Alveolar and tracheobronchial doses of particle for a single puff were estimated;•Comparisons with conventional cigarette were made.
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ISSN:0041-008X
1096-0333
1096-0333
DOI:10.1016/j.taap.2014.04.004