Quality of life after percutaneous paravalvular leak closure – a prospective registry

• Published in: Postępy w kardiologii interwencyjnej Vol. 18; no. 3; pp. 261 - 268
• Main Authors: Kozlowski, Michal, Malczewska, Magdalena, Pysz, Piotr, Jędrzejek, Marek, Wojakowski, Wojciech, Smolka, Grzegorz
• Format: Journal Article
• Language: English
• Published: Poland Termedia Publishing House 01.09.2022
• Subjects: heart failure; Original Paper; paravalvular leak; quality of life; structural heart diseases; heart failure; paravalvular leak; structural heart diseases; quality of life
• ISSN: 1734-9338; 1897-4295
• DOI: 10.5114/aic.2022.120451

Presence of paravalvular leaks (PVLs) can lead to heart failure, which decreases quality of life (QoL). Percutaneous closure is becoming the first-line treatment of PVLs, but whether such a procedure could improve QoL in these patients has never been examined. To examine changes in scores of the Minnesota Living with Heart Failure Questionnaire (MLHFQ) and Kansas City Cardiomyopathy Questionnaire (KCCQ) after percutaneous PVL closure. Forty subjects with heart failure symptoms and at least moderate PVL were included in this prospective registry. QoL was assessed at baseline and during a 12-month follow-up after percutaneous PVL closure by MLHFQ and KCCQ questionnaires. Changes in NT-proBNP and lactate dehydrogenase (LDH) levels were also analyzed. Technical success (TS) was achieved in 97.5% of cases and procedural success (PS) in 85% of cases. In the group with PS a significant decrease in MLHFQ score as well as an increase in scores of all KCCQ domains was observed. No statistically significant changes were observed in the group without PS, mainly due to the small sample size. Percutaneous PVL closure is associated with better QoL during a 12-month follow-up provided PS was achieved. Due to the low number of subjects in whom PS was not achieved, it is not possible to determine the influence of a failed procedure in this group of patients.