Decreased serum 1,5-anhydroglucitol in nondiabetic subjects with a family history of NIDDM

• Published in: Diabetes Caer Vol. 19; no. 9; pp. 940 - 944
• Main Authors: Tsukui, Satoshi, Fukumura, Yukihito, Kobayashi, Isao
• Format: Journal Article
• Language: English
• Published: Alexandria, VA American Diabetes Association 01.09.1996
• Subjects: Analysis of Variance; Biological and medical sciences; Biomarkers; Biomarkers - blood; Blood Glucose; Blood Glucose - metabolism; Deoxyglucose; Deoxyglucose - blood; Diabetes Mellitus, Type 2; Diabetes Mellitus, Type 2 - genetics; Diabetes. Impaired glucose tolerance; Endocrine pancreas. Apud cells (diseases); Endocrinopathies; Etiopathogenesis. Screening. Investigations. Target tissue resistance; Glucose Intolerance; Glucose Intolerance - blood; Glucose Tolerance Test; Glycated Hemoglobin; Glycated Hemoglobin A - analysis; Glycosuria; Humans; Isomerism; Medical sciences; Middle Aged; Nuclear Family; Reference Values; Human; Family story; Family study; Hemoglobin A1c; Exploration; Metabolic diseases; Glucose tolerance test; Non insulin dependent diabetes; Quantitative analysis
• ISSN: 0149-5992; 1935-5548
• DOI: 10.2337/diacare.19.9.940

Decreased serum 1,5-anhydroglucitol in nondiabetic subjects with a family history of NIDDM. S Tsukui , Y Fukumura and I Kobayashi Department of Laboratory Medicine, Gunma University School of Medicine, Japan. pxk04327@niftyserve.or.jp Abstract OBJECTIVE: To investigate the effect of a family history of NIDDM on HbAlc and serum 1,5-anhydroglucitol (AG) in nondiabetic subjects. RESEARCH DESIGN AND METHODS: A 75-g oral glucose tolerance test was performed; 258 subjects with normal glucose tolerance and 106 subjects with impaired glucose tolerance (IGT) were selected HbAlc and serum AG were compared between subjects with and without a family history of NIDDM. The relationships between age, BMI, HbAlc, serum AG, fasting and 2-h plasma glucose, and urinary glucose were also examined using principal component analysis with a varimax rotation. RESULTS: In the normal group, only serum AG was lower in subjects with a positive family history than in those with no family history. On the other hand, in the IGT group, subjects with a positive family history were younger and had a higher 2-h plasma glucose, a higher urinary glucose, and a lower serum AG than those with no family history, whereas there was no difference in HbAlc. Principal component analysis identified three factors. The first factor, a linear combination of HbAlc and fasting plasma glucose, was labeled an average glycemic factor. The second factor, which included serum AG, 2-h plasma glucose, and urinary glucose, was labeled an oscillatory glycemic factor. The third factor, which contrasted age against BMI, was labeled an environmental factor. CONCLUSIONS: Serum AG is related to glycosuria even among nondiabetic subjects, and its concentrations are decreased in those with a family history of NIDDM. Our results suggest that serum AG rather than HbAlc reflects early metabolic abnormalities in these subjects.