Genome-Wide Studies in Ischaemic Stroke: Are Genetics Only Useful for Finding Genes?

• Published in: International journal of molecular sciences Vol. 23; no. 12; p. 6840
• Main Authors: Gallego-Fabrega, Cristina, Muiño, Elena, Cárcel-Márquez, Jara, Llucià-Carol, Laia, Lledós, Miquel, Martín-Campos, Jesús M., Cullell, Natalia, Fernández-Cadenas, Israel
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 20.06.2022; MDPI
• Subjects: Atherosclerosis; Biobanks; Blood pressure; Brain Ischemia - genetics; Cardiac arrhythmia; Cardiovascular disease; Consortia; Genes; Genetics; Genome-Wide Association Study; Genomes; Health risk assessment; Humans; Ischemia; Ischemic Stroke; Meta-analysis; Review; Risk Factors; Stroke; Stroke - genetics; GWAS; microbiome; stroke; epigenetics
• ISSN: 1422-0067; 1661-6596; 1422-0067
• DOI: 10.3390/ijms23126840

Ischaemic stroke is a complex disease with some degree of heritability. This means that heritability factors, such as genetics, could be risk factors for ischaemic stroke. The era of genome-wide studies has revealed some of these heritable risk factors, although the data generated by these studies may also be useful in other disciplines. Analysis of these data can be used to understand the biological mechanisms associated with stroke risk and stroke outcome, to determine the causality between stroke and other diseases without the need for expensive clinical trials, or to find potential drug targets with higher success rates than other strategies. In this review we will discuss several of the most relevant studies regarding the genetics of ischaemic stroke and the potential use of the data generated.