Improvement in cerebral function with treatment of posttraumatic stress disorder
Posttraumatic stress disorder (PTSD) and mild traumatic brain injury (mTBI) are signature illnesses of the Iraq and Afghanistan wars, but current diagnostic and therapeutic measures for these conditions are suboptimal. In our study, functional magnetic resonance imaging (fMRI) is used to try to diff...
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| Published in | Annals of the New York Academy of Sciences Vol. 1208; no. 1; pp. 142 - 149 |
|---|---|
| Main Authors | , , , , , , , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Malden, USA
Blackwell Publishing Inc
01.10.2010
Wiley Subscription Services, Inc |
| Subjects | |
| Online Access | Get full text |
| ISSN | 0077-8923 1749-6632 1749-6632 |
| DOI | 10.1111/j.1749-6632.2010.05689.x |
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| Abstract | Posttraumatic stress disorder (PTSD) and mild traumatic brain injury (mTBI) are signature illnesses of the Iraq and Afghanistan wars, but current diagnostic and therapeutic measures for these conditions are suboptimal. In our study, functional magnetic resonance imaging (fMRI) is used to try to differentiate military service members with: PTSD and mTBI, PTSD alone, mTBI alone, and neither PTSD nor mTBI. Those with PTSD are then randomized to virtual reality exposure therapy or imaginal exposure. fMRI is repeated after treatment and along with the Clinician‐Administered PTSD Scale (CAPS) and Clinical Global Impression (CGI) scores to compare with baseline. Twenty subjects have completed baseline fMRI scans, including four controls and one mTBI only; of 15 treated for PTSD, eight completed posttreatment scans. Most subjects have been male (93%) and Caucasian (83%), with a mean age of 34. Significant improvements are evident on fMRI scans, and corroborated by CGI scores, but CAPS scores improvements are modest. In conclusion, CGI scores and fMRI scans indicate significant improvement in PTSD in both treatment arms, though CAPS score improvements are less robust. |
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| AbstractList | Posttraumatic stress disorder (PTSD) and mild traumatic brain injury (mTBI) are signature illnesses of the Iraq and Afghanistan wars, but current diagnostic and therapeutic measures for these conditions are suboptimal. In our study, functional magnetic resonance imaging (fMRI) is used to try to differentiate military service members with: PTSD and mTBI, PTSD alone, mTBI alone, and neither PTSD nor mTBI. Those with PTSD are then randomized to virtual reality exposure therapy or imaginal exposure. fMRI is repeated after treatment and along with the Clinician-Administered PTSD Scale (CAPS) and Clinical Global Impression (CGI) scores to compare with baseline. Twenty subjects have completed baseline fMRI scans, including four controls and one mTBI only; of 15 treated for PTSD, eight completed posttreatment scans. Most subjects have been male (93%) and Caucasian (83%), with a mean age of 34. Significant improvements are evident on fMRI scans, and corroborated by CGI scores, but CAPS scores improvements are modest. In conclusion, CGI scores and fMRI scans indicate significant improvement in PTSD in both treatment arms, though CAPS score improvements are less robust. Posttraumatic stress disorder (PTSD) and mild traumatic brain injury (mTBI) are signature illnesses of the Iraq and Afghanistan wars, but current diagnostic and therapeutic measures for these conditions are suboptimal. In our study, functional magnetic resonance imaging (fMRI) is used to try to differentiate military service members with: PTSD and mTBI, PTSD alone, mTBI alone, and neither PTSD nor mTBI. Those with PTSD are then randomized to virtual reality exposure therapy or imaginal exposure. fMRI is repeated after treatment and along with the Clinician-Administered PTSD Scale (CAPS) and Clinical Global Impression (CGI) scores to compare with baseline. Twenty subjects have completed baseline fMRI scans, including four controls and one mTBI only; of 15 treated for PTSD, eight completed posttreatment scans. Most subjects have been male (93%) and Caucasian (83%), with a mean age of 34. Significant improvements are evident on fMRI scans, and corroborated by CGI scores, but CAPS scores improvements are modest. In conclusion, CGI scores and fMRI scans indicate significant improvement in PTSD in both treatment arms, though CAPS score improvements are less robust. [PUBLICATION ABSTRACT] Posttraumatic stress disorder (PTSD) and mild traumatic brain injury (mTBI) are signature illnesses of the Iraq and Afghanistan wars, but current diagnostic and therapeutic measures for these conditions are suboptimal. In our study, functional magnetic resonance imaging (fMRI) is used to try to differentiate military service members with: PTSD and mTBI, PTSD alone, mTBI alone, and neither PTSD nor mTBI. Those with PTSD are then randomized to virtual reality exposure therapy or imaginal exposure. fMRI is repeated after treatment and along with the Clinician-Administered PTSD Scale (CAPS) and Clinical Global Impression (CGI) scores to compare with baseline. Twenty subjects have completed baseline fMRI scans, including four controls and one mTBI only; of 15 treated for PTSD, eight completed posttreatment scans. Most subjects have been male (93%) and Caucasian (83%), with a mean age of 34. Significant improvements are evident on fMRI scans, and corroborated by CGI scores, but CAPS scores improvements are modest. In conclusion, CGI scores and fMRI scans indicate significant improvement in PTSD in both treatment arms, though CAPS score improvements are less robust.Posttraumatic stress disorder (PTSD) and mild traumatic brain injury (mTBI) are signature illnesses of the Iraq and Afghanistan wars, but current diagnostic and therapeutic measures for these conditions are suboptimal. In our study, functional magnetic resonance imaging (fMRI) is used to try to differentiate military service members with: PTSD and mTBI, PTSD alone, mTBI alone, and neither PTSD nor mTBI. Those with PTSD are then randomized to virtual reality exposure therapy or imaginal exposure. fMRI is repeated after treatment and along with the Clinician-Administered PTSD Scale (CAPS) and Clinical Global Impression (CGI) scores to compare with baseline. Twenty subjects have completed baseline fMRI scans, including four controls and one mTBI only; of 15 treated for PTSD, eight completed posttreatment scans. Most subjects have been male (93%) and Caucasian (83%), with a mean age of 34. Significant improvements are evident on fMRI scans, and corroborated by CGI scores, but CAPS scores improvements are modest. In conclusion, CGI scores and fMRI scans indicate significant improvement in PTSD in both treatment arms, though CAPS score improvements are less robust. |
| Author | Roy, Michael J. Francis, Jennifer Difede, Joann Rothbaum, Barbara Friedlander, Joshua Lande, Raymond G. Yu, Henry Blair, James Law, Wendy Tarpley, Vanita Patt, Ivy Taylor, Patricia Banks-Williams, Lisa Rizzo, Albert McLellan, Jennifer Mallinger, Alan |
| Author_xml | – sequence: 1 givenname: Michael J. surname: Roy fullname: Roy, Michael J. organization: Uniformed Services University, Bethesda, Maryland, and Walter Reed Army Medical Center, Washington, DC – sequence: 2 givenname: Jennifer surname: Francis fullname: Francis, Jennifer organization: Uniformed Services University, Bethesda, Maryland, and Walter Reed Army Medical Center, Washington, DC – sequence: 3 givenname: Joshua surname: Friedlander fullname: Friedlander, Joshua organization: Uniformed Services University, Bethesda, Maryland, and Walter Reed Army Medical Center, Washington, DC – sequence: 4 givenname: Lisa surname: Banks-Williams fullname: Banks-Williams, Lisa organization: Uniformed Services University, Bethesda, Maryland, and Walter Reed Army Medical Center, Washington, DC – sequence: 5 givenname: Raymond G. surname: Lande fullname: Lande, Raymond G. organization: Uniformed Services University, Bethesda, Maryland, and Walter Reed Army Medical Center, Washington, DC – sequence: 6 givenname: Patricia surname: Taylor fullname: Taylor, Patricia organization: Uniformed Services University, Bethesda, Maryland, and Walter Reed Army Medical Center, Washington, DC – sequence: 7 givenname: James surname: Blair fullname: Blair, James organization: National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland – sequence: 8 givenname: Jennifer surname: McLellan fullname: McLellan, Jennifer organization: National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland – sequence: 9 givenname: Wendy surname: Law fullname: Law, Wendy organization: Uniformed Services University, Bethesda, Maryland, and Walter Reed Army Medical Center, Washington, DC – sequence: 10 givenname: Vanita surname: Tarpley fullname: Tarpley, Vanita organization: Uniformed Services University, Bethesda, Maryland, and Walter Reed Army Medical Center, Washington, DC – sequence: 11 givenname: Ivy surname: Patt fullname: Patt, Ivy organization: Uniformed Services University, Bethesda, Maryland, and Walter Reed Army Medical Center, Washington, DC – sequence: 12 givenname: Henry surname: Yu fullname: Yu, Henry organization: National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland – sequence: 13 givenname: Alan surname: Mallinger fullname: Mallinger, Alan organization: National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland – sequence: 14 givenname: Joann surname: Difede fullname: Difede, Joann organization: Weill Medical College of Cornell University, New York, New York – sequence: 15 givenname: Albert surname: Rizzo fullname: Rizzo, Albert organization: Institute for Creative Technologies, University of Southern California, Los Angeles, California – sequence: 16 givenname: Barbara surname: Rothbaum fullname: Rothbaum, Barbara organization: Emory University School of Medicine, Atlanta, Georgia |
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| Title | Improvement in cerebral function with treatment of posttraumatic stress disorder |
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