Synthesis of novel 3-allylseleno-6-alkylthiopyridazines: their anticancer activity against MCF-7 cells

A new series of 3-allylseleno-6-alkylthiopyridazines 6a – 6g was synthesized by two synthetic routes from 3,6-dichloropyridazine to develop new anticancer agents. These new compounds showed antiproliferative activities against breast cancer (MCF-7) cells in CCK-8 assays, and could be promising candi...

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Published in	Archives of pharmacal research Vol. 37; no. 4; pp. 452 - 458
Main Authors	Kim, Chaewon, Kim, Saet-Byeul, Park, Myung-Sook
Format	Journal Article
Language	English
Published	Heidelberg Pharmaceutical Society of Korea 01.04.2014 대한약학회
Subjects	anticarcinogenic activity antineoplastic agents Antineoplastic Agents - chemical synthesis Antineoplastic Agents - pharmacology breast neoplasms carcinoma cell growth Drug Screening Assays, Antitumor drug therapy Humans MCF-7 Cells Medicine Pharmacology/Toxicology Pharmacy Pyridazines - chemical synthesis Pyridazines - pharmacology Research Article Structure-Activity Relationship 약학 Pyridazines Anticancer activities MCF-7 cells Organoseleniums Allylselenopyridazines
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ISSN	0253-6269 1976-3786 1976-3786
DOI	10.1007/s12272-013-0244-x

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Abstract	A new series of 3-allylseleno-6-alkylthiopyridazines 6a – 6g was synthesized by two synthetic routes from 3,6-dichloropyridazine to develop new anticancer agents. These new compounds showed antiproliferative activities against breast cancer (MCF-7) cells in CCK-8 assays, and could be promising candidates for chemotherapy of carcinomas. Compound 6e (3-allylseleno-6-pentylthiopyridazine) showed higher potency than 5FU for inhibiting the growth of these cell lines. This suggests the potential anticancer activity of compound 6e .
AbstractList	A new series of 3-allylseleno-6-alkylthiopyridazines 6a – 6g was synthesized by two synthetic routes from 3,6-dichloropyridazine to develop new anticancer agents. These new compounds showed antiproliferative activities against breast cancer (MCF-7) cells in CCK-8 assays, and could be promising candidates for chemotherapy of carcinomas. Compound 6e (3-allylseleno-6-pentylthiopyridazine) showed higher potency than 5FU for inhibiting the growth of these cell lines. This suggests the potential anticancer activity of compound 6e . A new series of 3-allylseleno-6-alkylthiopyridazines6a–6g was synthesized by two synthetic routesfrom 3,6-dichloropyridazine to develop new anticanceragents. These new compounds showed antiproliferativeactivities against breast cancer (MCF-7) cells in CCK-8assays, and could be promising candidates for chemotherapyof carcinomas. Compound 6e (3-allylseleno-6-pentylthiopyridazine)showed higher potency than 5FU forinhibiting the growth of these cell lines. This suggests thepotential anticancer activity of compound 6e. KCI Citation Count: 10 A new series of 3-allylseleno-6-alkylthiopyridazines 6a-6g was synthesized by two synthetic routes from 3,6-dichloropyridazine to develop new anticancer agents. These new compounds showed antiproliferative activities against breast cancer (MCF-7) cells in CCK-8 assays, and could be promising candidates for chemotherapy of carcinomas. Compound 6e (3-allylseleno-6-pentylthiopyridazine) showed higher potency than 5FU for inhibiting the growth of these cell lines. This suggests the potential anticancer activity of compound 6e. A new series of 3-allylseleno-6-alkylthiopyridazines 6a-6g was synthesized by two synthetic routes from 3,6-dichloropyridazine to develop new anticancer agents. These new compounds showed antiproliferative activities against breast cancer (MCF-7) cells in CCK-8 assays, and could be promising candidates for chemotherapy of carcinomas. Compound 6e (3-allylseleno-6-pentylthiopyridazine) showed higher potency than 5FU for inhibiting the growth of these cell lines. This suggests the potential anticancer activity of compound 6e.A new series of 3-allylseleno-6-alkylthiopyridazines 6a-6g was synthesized by two synthetic routes from 3,6-dichloropyridazine to develop new anticancer agents. These new compounds showed antiproliferative activities against breast cancer (MCF-7) cells in CCK-8 assays, and could be promising candidates for chemotherapy of carcinomas. Compound 6e (3-allylseleno-6-pentylthiopyridazine) showed higher potency than 5FU for inhibiting the growth of these cell lines. This suggests the potential anticancer activity of compound 6e.
Author	Kim, Chaewon Kim, Saet-Byeul Park, Myung-Sook
Author_xml	– sequence: 1 givenname: Chaewon surname: Kim fullname: Kim, Chaewon organization: College of Pharmacy, Duksung Women’s University – sequence: 2 givenname: Saet-Byeul surname: Kim fullname: Kim, Saet-Byeul organization: College of Pharmacy, Duksung Women’s University – sequence: 3 givenname: Myung-Sook surname: Park fullname: Park, Myung-Sook email: mspark@duksung.ac.kr organization: College of Pharmacy, Duksung Women’s University
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Cites_doi	10.1002/ejoc.200600044 10.1007/BF02976691 10.1007/s12272-010-0201-x 10.1002/(SICI)1098-1128(199601)16:1<111::AID-MED4>3.0.CO;2-5 10.1021/ja01239a049 10.1016/S0022-328X(02)01627-3 10.1016/0304-3835(91)90171-D 10.1021/jm201758g 10.1016/S0959-8049(01)00242-8 10.5012/jkcs.2011.55.3.546 10.5012/jkcs.2007.51.3.244 10.1016/j.jorganchem.2004.07.040 10.1007/s12272-013-0144-0 10.1021/ja00282a033 10.1007/BF02977666 10.1007/s11814-008-0241-9 10.1007/s12272-013-0007-8 10.5012/bkcs.2009.30.1.083
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Snippet	A new series of 3-allylseleno-6-alkylthiopyridazines 6a – 6g was synthesized by two synthetic routes from 3,6-dichloropyridazine to develop new anticancer... A new series of 3-allylseleno-6-alkylthiopyridazines 6a-6g was synthesized by two synthetic routes from 3,6-dichloropyridazine to develop new anticancer... A new series of 3-allylseleno-6-alkylthiopyridazines 6a–6g was synthesized by two synthetic routes from 3,6-dichloropyridazine to develop new anticancer... A new series of 3-allylseleno-6-alkylthiopyridazines6a–6g was synthesized by two synthetic routesfrom 3,6-dichloropyridazine to develop new anticanceragents....
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SubjectTerms	anticarcinogenic activity antineoplastic agents Antineoplastic Agents - chemical synthesis Antineoplastic Agents - pharmacology breast neoplasms carcinoma cell growth Drug Screening Assays, Antitumor drug therapy Humans MCF-7 Cells Medicine Pharmacology/Toxicology Pharmacy Pyridazines - chemical synthesis Pyridazines - pharmacology Research Article Structure-Activity Relationship 약학
Title	Synthesis of novel 3-allylseleno-6-alkylthiopyridazines: their anticancer activity against MCF-7 cells
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