Synthesis of novel 3-allylseleno-6-alkylthiopyridazines: their anticancer activity against MCF-7 cells

• Published in: Archives of pharmacal research Vol. 37; no. 4; pp. 452 - 458
• Main Authors: Kim, Chaewon, Kim, Saet-Byeul, Park, Myung-Sook
• Format: Journal Article
• Language: English
• Published: Heidelberg Pharmaceutical Society of Korea 01.04.2014; 대한약학회
• Subjects: anticarcinogenic activity; antineoplastic agents; Antineoplastic Agents - chemical synthesis; Antineoplastic Agents - pharmacology; breast neoplasms; carcinoma; cell growth; Drug Screening Assays, Antitumor; drug therapy; Humans; MCF-7 Cells; Medicine; Pharmacology/Toxicology; Pharmacy; Pyridazines - chemical synthesis; Pyridazines - pharmacology; Research Article; Structure-Activity Relationship; 약학; Pyridazines; Anticancer activities; MCF-7 cells; Organoseleniums; Allylselenopyridazines
• ISSN: 0253-6269; 1976-3786; 1976-3786
• DOI: 10.1007/s12272-013-0244-x

A new series of 3-allylseleno-6-alkylthiopyridazines 6a – 6g was synthesized by two synthetic routes from 3,6-dichloropyridazine to develop new anticancer agents. These new compounds showed antiproliferative activities against breast cancer (MCF-7) cells in CCK-8 assays, and could be promising candidates for chemotherapy of carcinomas. Compound 6e (3-allylseleno-6-pentylthiopyridazine) showed higher potency than 5FU for inhibiting the growth of these cell lines. This suggests the potential anticancer activity of compound 6e .