Modeling Alzheimer’s disease brains in vitro

Alzheimer’s disease (AD) research is hampered by a lack of models that recapitulate all key disease features. Park et al. introduce a microfluidic device containing a 3D culture of human neurons, astrocytes, and microglia that develop AD-like pathology, revealing a potentially important inflammatory...

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Published inNature neuroscience Vol. 21; no. 7; pp. 899 - 900
Main Authors Henstridge, Christopher M., Spires-Jones, Tara L.
Format Journal Article
LanguageEnglish
Published New York Nature Publishing Group US 01.07.2018
Nature Publishing Group
Subjects
13/62
631/378/1689
692/699/375
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Alzheimer Disease
Alzheimer's disease
Analysis
Animal Genetics and Genomics
Apoptosis
Astrocytes
Behavioral Sciences
Biological Techniques
Biomedical and Life Sciences
Biomedicine
Brain
Brain research
Dementia
Health aspects
Humans
Immunology
Inflammation
Medical research
Microfluidic devices
Microfluidics
Microglia
Mutation
Neurobiology
Neurodegeneration
Neurons
Neurosciences
Neurotoxicity
News & Views
news-and-views
Parks
Pathology
Proteins
Psychological aspects
Stem cells
Therapeutics
Tumor necrosis factor-TNF
Universities and colleges
Online AccessGet full text
ISSN1097-6256
1546-1726
1546-1726
DOI10.1038/s41593-018-0177-2

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Abstract Alzheimer’s disease (AD) research is hampered by a lack of models that recapitulate all key disease features. Park et al. introduce a microfluidic device containing a 3D culture of human neurons, astrocytes, and microglia that develop AD-like pathology, revealing a potentially important inflammatory mechanism of neurodegeneration.
AbstractList Alzheimer’s disease (AD) research is hampered by a lack of models that recapitulate all key disease features. Park et al. introduce a microfluidic device containing a 3D culture of human neurons, astrocytes, and microglia that develop AD-like pathology, revealing a potentially important inflammatory mechanism of neurodegeneration.
Audience Academic
Author Henstridge, Christopher M.
Spires-Jones, Tara L.
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Cites_doi 10.1016/j.neuron.2017.03.042
10.1056/NEJMoa010178
10.1038/nature13800
10.1038/nn.4534
10.1126/science.aad8373
10.1016/j.cell.2015.12.056
10.1007/s40266-015-0239-z
10.1016/j.stemcr.2017.05.017
10.1016/j.conb.2015.10.004
10.1101/cshperspect.a006346
10.1186/s13195-017-0268-4
10.1007/s00401-017-1709-7
10.15252/embj.201797397
10.1038/s41593-018-0175-4
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References Wyss-CorayTRogersJCold Spring Harb. Perspect. Med.20122a00634610.1101/cshperspect.a006346
ArberCLovejoyCWraySAlzheimers Res. Ther.201794210.1186/s13195-017-0268-4
WHO. Dementia, a global health priority. World Health Organizationhttp://www.who.int/mental_health/publications/dementia_report_2012/en/ (2017).
Park, J. et al. Nat. Neurosci.21, https://doi.org/10.1038/s41593-018-0175-4 (2018).
AbudEMNeuron201794278293.e91:CAS:528:DC%2BC2sXmsVWgsbg%3D10.1016/j.neuron.2017.03.042
PandyaHNat. Neurosci.2017207537591:CAS:528:DC%2BC2sXltVWntL8%3D10.1038/nn.4534
HaenselerWStem Cell Rep.20178172717421:CAS:528:DC%2BC2sXpslWgt74%3D10.1016/j.stemcr.2017.05.017
Miguel-ÁlvarezMDrugs Aging20153213914710.1007/s40266-015-0239-z
SasaguriHEMBO J.201736247324871:CAS:528:DC%2BC2sXht1GgurzN10.15252/embj.201797397
in t’ VeldBAN. Engl. J. Med.20013451515152110.1056/NEJMoa010178
Spires-JonesTLAttemsJThalDRActa Neuropathol.20171341872051:CAS:528:DC%2BC2sXlvVOhsbw%3D10.1007/s00401-017-1709-7
De StrooperBKarranECell201616460361510.1016/j.cell.2015.12.056
ChoiSHNature20145152742781:CAS:528:DC%2BC2cXhvVemtr3L10.1038/nature13800
HongSScience20163527127161:CAS:528:DC%2BC28XntVeqt74%3D10.1126/science.aad8373
Villegas-LlerenaCPhillipsAGarcia-ReitboeckPHardyJPocockJMCurr. Opin. Neurobiol.20163674811:CAS:528:DC%2BC2MXhs1Ort73N10.1016/j.conb.2015.10.004
C Villegas-Llerena (177_CR9) 2016; 36
W Haenseler (177_CR11) 2017; 8
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177_CR3
B Strooper De (177_CR5) 2016; 164
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S Hong (177_CR10) 2016; 352
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M Miguel-Álvarez (177_CR8) 2015; 32
29950669 - Nat Neurosci. 2018 Jul;21(7):941-951
References_xml – reference: Park, J. et al. Nat. Neurosci.21, https://doi.org/10.1038/s41593-018-0175-4 (2018).
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– reference: WHO. Dementia, a global health priority. World Health Organizationhttp://www.who.int/mental_health/publications/dementia_report_2012/en/ (2017).
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– reference: SasaguriHEMBO J.201736247324871:CAS:528:DC%2BC2sXht1GgurzN10.15252/embj.201797397
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– reference: HongSScience20163527127161:CAS:528:DC%2BC28XntVeqt74%3D10.1126/science.aad8373
– reference: Miguel-ÁlvarezMDrugs Aging20153213914710.1007/s40266-015-0239-z
– reference: Villegas-LlerenaCPhillipsAGarcia-ReitboeckPHardyJPocockJMCurr. Opin. Neurobiol.20163674811:CAS:528:DC%2BC2MXhs1Ort73N10.1016/j.conb.2015.10.004
– reference: AbudEMNeuron201794278293.e91:CAS:528:DC%2BC2sXmsVWgsbg%3D10.1016/j.neuron.2017.03.042
– reference: in t’ VeldBAN. Engl. J. Med.20013451515152110.1056/NEJMoa010178
– reference: Wyss-CorayTRogersJCold Spring Harb. Perspect. Med.20122a00634610.1101/cshperspect.a006346
– volume: 94
  start-page: 278
  year: 2017
  ident: 177_CR12
  publication-title: Neuron
  doi: 10.1016/j.neuron.2017.03.042
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  start-page: 1515
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  ident: 177_CR7
  publication-title: N. Engl. J. Med.
  doi: 10.1056/NEJMoa010178
– ident: 177_CR1
– volume: 515
  start-page: 274
  year: 2014
  ident: 177_CR4
  publication-title: Nature
  doi: 10.1038/nature13800
– volume: 20
  start-page: 753
  year: 2017
  ident: 177_CR13
  publication-title: Nat. Neurosci.
  doi: 10.1038/nn.4534
– volume: 352
  start-page: 712
  year: 2016
  ident: 177_CR10
  publication-title: Science
  doi: 10.1126/science.aad8373
– volume: 164
  start-page: 603
  year: 2016
  ident: 177_CR5
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– volume: 32
  start-page: 139
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  ident: 177_CR8
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  start-page: 1727
  year: 2017
  ident: 177_CR11
  publication-title: Stem Cell Rep.
  doi: 10.1016/j.stemcr.2017.05.017
– volume: 36
  start-page: 74
  year: 2016
  ident: 177_CR9
  publication-title: Curr. Opin. Neurobiol.
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– volume: 2
  start-page: a006346
  year: 2012
  ident: 177_CR6
  publication-title: Cold Spring Harb. Perspect. Med.
  doi: 10.1101/cshperspect.a006346
– volume: 9
  start-page: 42
  year: 2017
  ident: 177_CR2
  publication-title: Alzheimers Res. Ther.
  doi: 10.1186/s13195-017-0268-4
– volume: 134
  start-page: 187
  year: 2017
  ident: 177_CR14
  publication-title: Acta Neuropathol.
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  doi: 10.15252/embj.201797397
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  doi: 10.1038/s41593-018-0175-4
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Snippet Alzheimer’s disease (AD) research is hampered by a lack of models that recapitulate all key disease features. Park et al. introduce a microfluidic device...
Alzheimer's disease (AD) research is hampered by a lack of models that recapitulate all key disease features. Park et al. introduce a microfluidic device...
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Alzheimer Disease
Alzheimer's disease
Analysis
Animal Genetics and Genomics
Apoptosis
Astrocytes
Behavioral Sciences
Biological Techniques
Biomedical and Life Sciences
Biomedicine
Brain
Brain research
Dementia
Health aspects
Humans
Immunology
Inflammation
Medical research
Microfluidic devices
Microfluidics
Microglia
Mutation
Neurobiology
Neurodegeneration
Neurons
Neurosciences
Neurotoxicity
News & Views
news-and-views
Parks
Pathology
Proteins
Psychological aspects
Stem cells
Therapeutics
Tumor necrosis factor-TNF
Universities and colleges
Title Modeling Alzheimer’s disease brains in vitro
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