Modeling Alzheimer’s disease brains in vitro

Alzheimer’s disease (AD) research is hampered by a lack of models that recapitulate all key disease features. Park et al. introduce a microfluidic device containing a 3D culture of human neurons, astrocytes, and microglia that develop AD-like pathology, revealing a potentially important inflammatory...

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Bibliographic Details
Published in	Nature neuroscience Vol. 21; no. 7; pp. 899 - 900
Main Authors	Henstridge, Christopher M., Spires-Jones, Tara L.
Format	Journal Article
Language	English
Published	New York Nature Publishing Group US 01.07.2018 Nature Publishing Group
Subjects	13/62 631/378/1689 692/699/375 Advertising executives Alzheimer Disease Alzheimer's disease Analysis Animal Genetics and Genomics Apoptosis Astrocytes Behavioral Sciences Biological Techniques Biomedical and Life Sciences Biomedicine Brain Brain research Dementia Health aspects Humans Immunology Inflammation Medical research Microfluidic devices Microfluidics Microglia Mutation Neurobiology Neurodegeneration Neurons Neurosciences Neurotoxicity News & Views news-and-views Parks Pathology Proteins Psychological aspects Stem cells Therapeutics Tumor necrosis factor-TNF Universities and colleges
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ISSN	1097-6256 1546-1726 1546-1726
DOI	10.1038/s41593-018-0177-2

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Summary:	Alzheimer’s disease (AD) research is hampered by a lack of models that recapitulate all key disease features. Park et al. introduce a microfluidic device containing a 3D culture of human neurons, astrocytes, and microglia that develop AD-like pathology, revealing a potentially important inflammatory mechanism of neurodegeneration.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 ObjectType-Commentary-3 content type line 23
ISSN:	1097-6256 1546-1726 1546-1726
DOI:	10.1038/s41593-018-0177-2