Characterization of ventricular arrhythmias and sudden cardiac death in subjects with mitral valve prolapse and mitral annular disjunction

• Published in: Heart rhythm Vol. 20; no. 1; pp. 112 - 121
• Main Authors: Raina, Anvi, Gersh, Bernard J., Asirvatham, Samuel J., Del-Carpio Munoz, Freddy
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.01.2023
• Subjects: Arrhythmias, Cardiac; Death, Sudden, Cardiac - epidemiology; Death, Sudden, Cardiac - etiology; Death, Sudden, Cardiac - prevention & control; Heart Valve Diseases - complications; Humans; Mitral annular disjunction; Mitral Valve; Mitral valve prolapse; Mitral Valve Prolapse - complications; Mitral Valve Prolapse - diagnosis; Risk stratification; Sudden cardiac death; Ventricular arrhythmias; Ventricular arrhythmias; Mitral valve prolapse; Mitral annular disjunction; Sudden cardiac death; Risk stratification
• ISSN: 1547-5271; 1556-3871; 1556-3871
• DOI: 10.1016/j.hrthm.2022.09.008

Sudden cardiac death is reported as the leading cause of mortality in developed nations. Arrhythmic mitral valve disease, encompassing mitral valve prolapse and/or mitral annular disjunction, is thought to be responsible in a sizable portion of these deaths. Despite this evidence, there are no reliable methods or clinically useful risk stratification schemes to determine which group of patients are at higher risk or may benefit from interventions such as catheter ablation or prophylactic implantation of a defibrillator. The reasons for this lack of guidance include our incomplete understanding of the mechanisms of ventricular arrhythmias and the fact that mitral valve prolapse and disjunction are frequently diagnosed, yet carry an overall low risk of sudden cardiac death. This heterogeneity makes the development of a reliable prediction model based on the presence of common risk factors very difficult. In this review, we summarize the relevant literature regarding the epidemiology, diagnosis, pathophysiology, and management of mitral valve prolapse and mitral annular disjunction and elucidate their role in sudden cardiac death.