Resveratrol and related stilbenes: Their anti-aging and anti-angiogenic properties

• Published in: Food and chemical toxicology Vol. 61; pp. 112 - 120
• Main Authors: Kasiotis, Konstantinos M., Pratsinis, Harris, Kletsas, Dimitris, Haroutounian, Serkos A.
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.11.2013
• Subjects: Aging; Aging - drug effects; Angiogenesis; Angiogenesis Inhibitors - pharmacology; Animals; Antineoplastic Agents, Phytogenic - pharmacology; antioxidants; Benzofurans - chemistry; Benzofurans - pharmacology; Dibenzocycloheptenes - pharmacology; Dietary Supplements; Humans; Lifespan; Plants - chemistry; Polyphenol; Resorcinols - pharmacology; Resveratrol; Rodentia; signal transduction; Stilbenes; Stilbenes - chemistry; Stilbenes - isolation & purification; Stilbenes - pharmacology; Aging; Angiogenesis; Polyphenol; Stilbenes; Lifespan; Resveratrol
• ISSN: 0278-6915; 1873-6351; 1873-6351
• DOI: 10.1016/j.fct.2013.03.038

Dietary stilbenes comprise a class of natural compounds that display significant biological activities of medicinal interest. Among them, their antioxidant, anti-aging and anti-angiogenesic properties are well established and subjects of numerous research endeavors. This mini-review aspires to account and present the literature reports published on research concerning various natural and synthetic stilbenes, such as trans-resveratrol. Special focus was given to most recent research findings, while the mechanisms underlying their anti-aging and anti-angiogenic effects as well as the respective signaling pathways involved were also presented and discussed.