Chlorhexidine hexametaphosphate as a wound care material coating: antimicrobial efficacy, toxicity and effect on healing
In this study, chlorhexidine hexametaphosphate (CHX-HMP) is investigated as a persistent antimicrobial coating for wound care materials. CHX-HMP was used as a wound care material coating and compared with chlorhexidine digluconate materials with respect to antimicrobial efficacy, toxicity and wound...
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Published in | Nanomedicine (London, England) Vol. 11; no. 16; pp. 2049 - 2057 |
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Main Authors | , , , , , , , |
Format | Journal Article |
Language | English |
Published |
England
Future Medicine Ltd
01.08.2016
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Subjects | |
Online Access | Get full text |
ISSN | 1743-5889 1748-6963 |
DOI | 10.2217/nnm-2016-0084 |
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Abstract | In this study, chlorhexidine hexametaphosphate (CHX-HMP) is investigated as a persistent antimicrobial coating for wound care materials.
CHX-HMP was used as a wound care material coating and compared with chlorhexidine digluconate materials with respect to antimicrobial efficacy, toxicity and wound closure.
Antimicrobial efficacy at day 1, 3 and 7 was observed with experimental and commercial materials. CHX-HMP coated materials had less toxic effect on human placental cells than commercial chlorhexidine dressings. CHX-HMP in pluronic gel did not delay healing but reduced wound colonization by
.
CHX-HMP could become a useful component of wound care materials with sustained antimicrobial efficacy, lower toxicity than chlorhexidine digluconate materials, and reduction in wound colonization without affecting closure. |
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AbstractList | In this study, chlorhexidine hexametaphosphate (CHX-HMP) is investigated as a persistent antimicrobial coating for wound care materials.
CHX-HMP was used as a wound care material coating and compared with chlorhexidine digluconate materials with respect to antimicrobial efficacy, toxicity and wound closure.
Antimicrobial efficacy at day 1, 3 and 7 was observed with experimental and commercial materials. CHX-HMP coated materials had less toxic effect on human placental cells than commercial chlorhexidine dressings. CHX-HMP in pluronic gel did not delay healing but reduced wound colonization by
.
CHX-HMP could become a useful component of wound care materials with sustained antimicrobial efficacy, lower toxicity than chlorhexidine digluconate materials, and reduction in wound colonization without affecting closure. In this study, chlorhexidine hexametaphosphate (CHX-HMP) is investigated as a persistent antimicrobial coating for wound care materials. CHX-HMP was used as a wound care material coating and compared with chlorhexidine digluconate materials with respect to antimicrobial efficacy, toxicity and wound closure. Antimicrobial efficacy at day 1, 3 and 7 was observed with experimental and commercial materials. CHX-HMP coated materials had less toxic effect on human placental cells than commercial chlorhexidine dressings. CHX-HMP in pluronic gel did not delay healing but reduced wound colonization by E. faecalis. CHX-HMP could become a useful component of wound care materials with sustained antimicrobial efficacy, lower toxicity than chlorhexidine digluconate materials, and reduction in wound colonization without affecting closure. Aim: In this study, chlorhexidine hexametaphosphate (CHX-HMP) is investigated as a persistent antimicrobial coating for wound care materials. Materials & methods: CHX-HMP was used as a wound care material coating and compared with chlorhexidine digluconate materials with respect to antimicrobial efficacy, toxicity and wound closure. Results: Antimicrobial efficacy at day 1, 3 and 7 was observed with experimental and commercial materials. CHX-HMP coated materials had less toxic effect on human placental cells than commercial chlorhexidine dressings. CHX-HMP in pluronic gel did not delay healing but reduced wound colonization by E. faecalis. Conclusion: CHX-HMP could become a useful component of wound care materials with sustained antimicrobial efficacy, lower toxicity than chlorhexidine digluconate materials, and reduction in wound colonization without affecting closure. |
Author | Barbour, Michele E Grady, Helena J Collins, Andrew M Maddocks, Sarah E Bass, Mark D Dommett, Rachel M Saunders, Margaret Roper, James A |
AuthorAffiliation | 3Bristol Centre for Functional Nanomaterials, University of Bristol, UK 4School of Biochemistry, University of Bristol, UK 5Centre for Membrane Interactions & Dynamics, Department of Biomedical Science, University of Sheffield, UK 1Oral Nanoscience, School of Oral & Dental Sciences, University of Bristol, UK 2School of Health Sciences, Cardiff Metropolitan University, UK 6School of Clinical Sciences, University of Bristol, UK 7Bioengineering, Innovation & Research Hub (BIRCH), University Hospitals Bristol, UK |
AuthorAffiliation_xml | – name: 5Centre for Membrane Interactions & Dynamics, Department of Biomedical Science, University of Sheffield, UK – name: 1Oral Nanoscience, School of Oral & Dental Sciences, University of Bristol, UK – name: 2School of Health Sciences, Cardiff Metropolitan University, UK – name: 3Bristol Centre for Functional Nanomaterials, University of Bristol, UK – name: 7Bioengineering, Innovation & Research Hub (BIRCH), University Hospitals Bristol, UK – name: 4School of Biochemistry, University of Bristol, UK – name: 6School of Clinical Sciences, University of Bristol, UK |
Author_xml | – sequence: 1 givenname: Michele E surname: Barbour fullname: Barbour, Michele E – sequence: 2 givenname: Sarah E surname: Maddocks fullname: Maddocks, Sarah E – sequence: 3 givenname: Helena J surname: Grady fullname: Grady, Helena J – sequence: 4 givenname: James A surname: Roper fullname: Roper, James A – sequence: 5 givenname: Mark D surname: Bass fullname: Bass, Mark D – sequence: 6 givenname: Andrew M surname: Collins fullname: Collins, Andrew M – sequence: 7 givenname: Rachel M surname: Dommett fullname: Dommett, Rachel M – sequence: 8 givenname: Margaret surname: Saunders fullname: Saunders, Margaret |
BackLink | https://www.ncbi.nlm.nih.gov/pubmed/27465012$$D View this record in MEDLINE/PubMed |
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CitedBy_id | crossref_primary_10_1016_j_actbio_2020_04_028 crossref_primary_10_1002_lsm_22614 crossref_primary_10_1016_j_actbio_2017_11_044 crossref_primary_10_1016_j_ejwf_2024_09_006 crossref_primary_10_3390_nano11020480 crossref_primary_10_1155_2021_7019130 crossref_primary_10_1016_j_dental_2021_02_007 crossref_primary_10_1021_acs_biomac_0c01709 crossref_primary_10_2217_nnm_2016_8000 crossref_primary_10_1136_bmjnph_2022_000431 crossref_primary_10_1007_s10856_020_06370_0 crossref_primary_10_1016_j_ijso_2022_100528 crossref_primary_10_1007_s10856_021_06616_5 crossref_primary_10_1093_jacamr_dlab027 crossref_primary_10_1080_02603594_2021_1973444 crossref_primary_10_1111_jerd_12413 |
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Snippet | In this study, chlorhexidine hexametaphosphate (CHX-HMP) is investigated as a persistent antimicrobial coating for wound care materials.
CHX-HMP was used as a... Aim: In this study, chlorhexidine hexametaphosphate (CHX-HMP) is investigated as a persistent antimicrobial coating for wound care materials. Materials &... |
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SubjectTerms | Adhesives Aging Animals Anti-Infective Agents, Local - chemistry Anti-Infective Agents, Local - pharmacology antimicrobial Aqueous solutions Bacteria - drug effects Bacterial Infections - prevention & control Biomedical materials catheter Catheters Cell Line chlorhexidine Chlorhexidine - analogs & derivatives Chlorhexidine - pharmacology Coated Materials, Biocompatible - chemistry Coated Materials, Biocompatible - pharmacology healing Humans Infections Mice, Inbred C57BL Nanoparticles Phosphates - chemistry Phosphates - pharmacology safety toxicity Transplants & implants wound care Wound healing Wound Healing - drug effects |
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Title | Chlorhexidine hexametaphosphate as a wound care material coating: antimicrobial efficacy, toxicity and effect on healing |
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