Chlorhexidine hexametaphosphate as a wound care material coating: antimicrobial efficacy, toxicity and effect on healing

In this study, chlorhexidine hexametaphosphate (CHX-HMP) is investigated as a persistent antimicrobial coating for wound care materials. CHX-HMP was used as a wound care material coating and compared with chlorhexidine digluconate materials with respect to antimicrobial efficacy, toxicity and wound...

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Published inNanomedicine (London, England) Vol. 11; no. 16; pp. 2049 - 2057
Main Authors Barbour, Michele E, Maddocks, Sarah E, Grady, Helena J, Roper, James A, Bass, Mark D, Collins, Andrew M, Dommett, Rachel M, Saunders, Margaret
Format Journal Article
LanguageEnglish
Published England Future Medicine Ltd 01.08.2016
Subjects
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ISSN1743-5889
1748-6963
DOI10.2217/nnm-2016-0084

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Abstract In this study, chlorhexidine hexametaphosphate (CHX-HMP) is investigated as a persistent antimicrobial coating for wound care materials. CHX-HMP was used as a wound care material coating and compared with chlorhexidine digluconate materials with respect to antimicrobial efficacy, toxicity and wound closure. Antimicrobial efficacy at day 1, 3 and 7 was observed with experimental and commercial materials. CHX-HMP coated materials had less toxic effect on human placental cells than commercial chlorhexidine dressings. CHX-HMP in pluronic gel did not delay healing but reduced wound colonization by . CHX-HMP could become a useful component of wound care materials with sustained antimicrobial efficacy, lower toxicity than chlorhexidine digluconate materials, and reduction in wound colonization without affecting closure.
AbstractList In this study, chlorhexidine hexametaphosphate (CHX-HMP) is investigated as a persistent antimicrobial coating for wound care materials. CHX-HMP was used as a wound care material coating and compared with chlorhexidine digluconate materials with respect to antimicrobial efficacy, toxicity and wound closure. Antimicrobial efficacy at day 1, 3 and 7 was observed with experimental and commercial materials. CHX-HMP coated materials had less toxic effect on human placental cells than commercial chlorhexidine dressings. CHX-HMP in pluronic gel did not delay healing but reduced wound colonization by . CHX-HMP could become a useful component of wound care materials with sustained antimicrobial efficacy, lower toxicity than chlorhexidine digluconate materials, and reduction in wound colonization without affecting closure.
In this study, chlorhexidine hexametaphosphate (CHX-HMP) is investigated as a persistent antimicrobial coating for wound care materials. CHX-HMP was used as a wound care material coating and compared with chlorhexidine digluconate materials with respect to antimicrobial efficacy, toxicity and wound closure. Antimicrobial efficacy at day 1, 3 and 7 was observed with experimental and commercial materials. CHX-HMP coated materials had less toxic effect on human placental cells than commercial chlorhexidine dressings. CHX-HMP in pluronic gel did not delay healing but reduced wound colonization by E. faecalis. CHX-HMP could become a useful component of wound care materials with sustained antimicrobial efficacy, lower toxicity than chlorhexidine digluconate materials, and reduction in wound colonization without affecting closure.
Aim: In this study, chlorhexidine hexametaphosphate (CHX-HMP) is investigated as a persistent antimicrobial coating for wound care materials. Materials & methods: CHX-HMP was used as a wound care material coating and compared with chlorhexidine digluconate materials with respect to antimicrobial efficacy, toxicity and wound closure. Results: Antimicrobial efficacy at day 1, 3 and 7 was observed with experimental and commercial materials. CHX-HMP coated materials had less toxic effect on human placental cells than commercial chlorhexidine dressings. CHX-HMP in pluronic gel did not delay healing but reduced wound colonization by E. faecalis. Conclusion: CHX-HMP could become a useful component of wound care materials with sustained antimicrobial efficacy, lower toxicity than chlorhexidine digluconate materials, and reduction in wound colonization without affecting closure.
Author Barbour, Michele E
Grady, Helena J
Collins, Andrew M
Maddocks, Sarah E
Bass, Mark D
Dommett, Rachel M
Saunders, Margaret
Roper, James A
AuthorAffiliation 3Bristol Centre for Functional Nanomaterials, University of Bristol, UK
4School of Biochemistry, University of Bristol, UK
5Centre for Membrane Interactions & Dynamics, Department of Biomedical Science, University of Sheffield, UK
1Oral Nanoscience, School of Oral & Dental Sciences, University of Bristol, UK
2School of Health Sciences, Cardiff Metropolitan University, UK
6School of Clinical Sciences, University of Bristol, UK
7Bioengineering, Innovation & Research Hub (BIRCH), University Hospitals Bristol, UK
AuthorAffiliation_xml – name: 5Centre for Membrane Interactions & Dynamics, Department of Biomedical Science, University of Sheffield, UK
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– name: 3Bristol Centre for Functional Nanomaterials, University of Bristol, UK
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– name: 4School of Biochemistry, University of Bristol, UK
– name: 6School of Clinical Sciences, University of Bristol, UK
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antimicrobial
healing
catheter
wound care
safety
chlorhexidine
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Snippet In this study, chlorhexidine hexametaphosphate (CHX-HMP) is investigated as a persistent antimicrobial coating for wound care materials. CHX-HMP was used as a...
Aim: In this study, chlorhexidine hexametaphosphate (CHX-HMP) is investigated as a persistent antimicrobial coating for wound care materials. Materials &...
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SubjectTerms Adhesives
Aging
Animals
Anti-Infective Agents, Local - chemistry
Anti-Infective Agents, Local - pharmacology
antimicrobial
Aqueous solutions
Bacteria - drug effects
Bacterial Infections - prevention & control
Biomedical materials
catheter
Catheters
Cell Line
chlorhexidine
Chlorhexidine - analogs & derivatives
Chlorhexidine - pharmacology
Coated Materials, Biocompatible - chemistry
Coated Materials, Biocompatible - pharmacology
healing
Humans
Infections
Mice, Inbred C57BL
Nanoparticles
Phosphates - chemistry
Phosphates - pharmacology
safety
toxicity
Transplants & implants
wound care
Wound healing
Wound Healing - drug effects
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Title Chlorhexidine hexametaphosphate as a wound care material coating: antimicrobial efficacy, toxicity and effect on healing
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