Chlorhexidine hexametaphosphate as a wound care material coating: antimicrobial efficacy, toxicity and effect on healing

• Published in: Nanomedicine (London, England) Vol. 11; no. 16; pp. 2049 - 2057
• Main Authors: Barbour, Michele E, Maddocks, Sarah E, Grady, Helena J, Roper, James A, Bass, Mark D, Collins, Andrew M, Dommett, Rachel M, Saunders, Margaret
• Format: Journal Article
• Language: English
• Published: England Future Medicine Ltd 01.08.2016
• Subjects: Adhesives; Aging; Animals; Anti-Infective Agents, Local - chemistry; Anti-Infective Agents, Local - pharmacology; antimicrobial; Aqueous solutions; Bacteria - drug effects; Bacterial Infections - prevention & control; Biomedical materials; catheter; Catheters; Cell Line; chlorhexidine; Chlorhexidine - analogs & derivatives; Chlorhexidine - pharmacology; Coated Materials, Biocompatible - chemistry; Coated Materials, Biocompatible - pharmacology; healing; Humans; Infections; Mice, Inbred C57BL; Nanoparticles; Phosphates - chemistry; Phosphates - pharmacology; safety; toxicity; Transplants & implants; wound care; Wound healing; Wound Healing - drug effects; United Kingdom > UK; toxicity; antimicrobial; healing; catheter; wound care; safety; chlorhexidine
• ISSN: 1743-5889; 1748-6963
• DOI: 10.2217/nnm-2016-0084

In this study, chlorhexidine hexametaphosphate (CHX-HMP) is investigated as a persistent antimicrobial coating for wound care materials. CHX-HMP was used as a wound care material coating and compared with chlorhexidine digluconate materials with respect to antimicrobial efficacy, toxicity and wound closure. Antimicrobial efficacy at day 1, 3 and 7 was observed with experimental and commercial materials. CHX-HMP coated materials had less toxic effect on human placental cells than commercial chlorhexidine dressings. CHX-HMP in pluronic gel did not delay healing but reduced wound colonization by . CHX-HMP could become a useful component of wound care materials with sustained antimicrobial efficacy, lower toxicity than chlorhexidine digluconate materials, and reduction in wound colonization without affecting closure.