Development of a novel electrospun nanofibrous delivery system for poorly water-soluble β-sitosterol

Electrospinning was used as a novel technique for fabricating polymeric nanofibers of a serum cholesterol lowering and poorly water-soluble plant sterol, β-sitosterol. Chitosan was used as a stabilizer/carrier polymer. The mean diameters of nanofibers ranged from 150 nm to 218 nm. β-sitosterol was i...

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Published inAsian journal of pharmceutical sciences Vol. 11; no. 4; pp. 500 - 506
Main Authors Paaver, Urve, Laidmäe, Ivo, Santos, Hélder A., Yliruusi, Jouko, Aruväli, Jaan, Kogermann, Karin, Heinämäki, Jyrki
Format Journal Article
LanguageEnglish
Published Elsevier B.V 01.08.2016
Elsevier
Subjects
Dissolution
Electrospinning
Nanofibers
Plant sterol
Solid-state properties
β-sitosterol
Solid-state properties
Electrospinning
Plant sterol
β-sitosterol
Nanofibers
Dissolution
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ISSN1818-0876
2221-285X
DOI10.1016/j.ajps.2016.04.005

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Summary:Electrospinning was used as a novel technique for fabricating polymeric nanofibers of a serum cholesterol lowering and poorly water-soluble plant sterol, β-sitosterol. Chitosan was used as a stabilizer/carrier polymer. The mean diameters of nanofibers ranged from 150 nm to 218 nm. β-sitosterol was in an amorphous form and homogeneously dispersed in the nanofibers. The β-sitosterol-loaded nanofibers were freely water-soluble and exhibited very short lag-time in releasing the plant sterol. The dissolution was associated with an immediate recrystallization of β-sitosterol in submicron level. In conclusion, electrospinning is a promising future technology for the formulation of poorly water-soluble plant sterols.
ISSN:1818-0876
2221-285X
DOI:10.1016/j.ajps.2016.04.005