Diabetic Nephropathy in KK and KK-Ay Mice

• Published in: EXPERIMENTAL ANIMALS Vol. 51; no. 2; pp. 191 - 196
• Main Authors: KIKUCHI, Takuya, OKAZAKI, Masako, OTA, Sumiko, MURAKAMI, Hidetomo, OGUCHI, Katsuji, SAITO, Yukako, UDAKA, Yuko, MARUYAMA, Mine
• Format: Journal Article
• Language: English
• Published: Japan Japanese Association for Laboratory Animal Science 01.04.2002
• Subjects: Albuminuria - genetics; Animals; Diabetic Nephropathies - blood; Diabetic Nephropathies - genetics; Diabetic Nephropathies - pathology; Diabetic Nephropathies - urine; diabetic nephropathy; Disease Models, Animal; Glycated Hemoglobin A - metabolism; Humans; Insulin - blood; Insulin Resistance; Kidney Glomerulus - pathology; KK mice; KK-Ay mice; Male; Mice; Mice, Inbred Strains - genetics; Mice, Mutant Strains - genetics; Species Specificity; Thrombomodulin - blood
• ISSN: 1341-1357; 0007-5124; 1884-4162; 1884-4170; 1881-7122; 1881-7122
• DOI: 10.1538/expanim.51.191

KK mice and KK-Ay mice were examined for age related changes in blood and urinary biophysiological parameters. Blood hemoglobin A1c levels were significantly higher in KK-Ay and KK mice as compared to non-diabetic ddY mice. In both diabetic mice, especially KK-Ay mice, plasma insulin levels markedly increased at 2 to 4 months of age, and the urinary glucose and microalbumin levels and albumin-to-creatinine ratios increased dependent on age. Plasma thrombomodulin levels significantly increased at 2 to 4 months of age in both KK and KK-Ay mice. Mild enlargement of mesengial matrix and segmental proliferative glomerular nephritis were revealed in KK and KK-Ay mice, respectively, at 4 months of age. KK-Ay mice with insulin resistance and high urine mAlb level might be useful as models for the early stage of diabetic nephropathy.