Programmable conformal transluminal ablation device for irregular remote small lesions

Development of micro-surgical robotic and high-resolution navigation techniques has enabled reach of micro-lesions in vivo. However, the small size, special shape, and location of these lesions make conformal treatment a challenge, especially for atherosclerotic lesion. A programmable conformal tran...

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Bibliographic Details
Published iniScience Vol. 28; no. 8; p. 113074
Main Authors Hou, Ruizhe, Wang, Hongying, Zou, Jincheng, Cao, Bo, Zhao, Shiqing, Zhang, Aili
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 15.08.2025
Elsevier
Subjects
Applied sciences
Health sciences
Natural sciences
Natural sciences
Health sciences
Applied sciences
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ISSN2589-0042
2589-0042
DOI10.1016/j.isci.2025.113074

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Summary:Development of micro-surgical robotic and high-resolution navigation techniques has enabled reach of micro-lesions in vivo. However, the small size, special shape, and location of these lesions make conformal treatment a challenge, especially for atherosclerotic lesion. A programmable conformal transluminal ablation device, including multi-channel and multi-level (MCML) radiofrequency (RF) system and RF balloon with circulating low-temperature flow inside, was designed to realize treatment for irregular remote lesions automatically. The system outputs different RF levels for each electrode. With embedding multi-physics-based algorithm, the system optimizes operating parameters and delivers energy accordingly for different targets, achieving sub-millimeter accuracy. Feasibility of the developed device was validated using both lesion-visible phantoms and ex vivo porcine vessels. For irregular lesions with different shapes and locations, the ablated region closely matched the target. The application of the developed system may also be extended for automatic programmable treatment of other transluminal targets such as lung cancer, and bladder cancer. [Display omitted] •A conformal transluminal ablation device was developed for irregular remote lesions•MCML radiofrequency system delivers different RF levels for each electrode•An NSGA-II-based algorithm optimizes conformal ablation treatment parameters•The transluminal balloon ablation device achieved sub-millimeter ablation accuracy Health sciences; Natural sciences; Applied sciences
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ISSN:2589-0042
2589-0042
DOI:10.1016/j.isci.2025.113074