Frequency and Outcomes of Periprocedural MI in Patients With Chronic Coronary Syndromes Undergoing PCI

• Published in: Journal of the American College of Cardiology Vol. 79; no. 6; pp. 513 - 526
• Main Authors: Ueki, Yasushi, Otsuka, Tatsuhiko, Bär, Sarah, Koskinas, Kostantinos C., Heg, Dik, Häner, Jonas, Siontis, George C.M., Praz, Fabien, Hunziker, Lukas, Lanz, Jonas, Stortecky, Stefan, Pilgrim, Thomas, Losdat, Sylvain, Windecker, Stephan, Räber, Lorenz
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 15.02.2022
• Subjects: Aged; Biomarkers - blood; Cardiovascular; chronic coronary syndrome; coronary artery disease; Coronary Artery Disease - complications; Coronary Artery Disease - surgery; Female; Follow-Up Studies; Humans; Incidence; Male; myocardial infarction; Myocardial Infarction - blood; Myocardial Infarction - epidemiology; Myocardial Infarction - etiology; Oligopeptides; Percutaneous Coronary Intervention; Prognosis; Registries; Retrospective Studies; Risk Factors; Syndrome; Troponin - blood; coronary artery disease; myocardial infarction; CK-MB; ECG; UDMI; ARC-2; URL; percutaneous coronary intervention; CCS; PCI; hs-cTn; MI; chronic coronary syndrome; SCAI; Society for Cardiovascular Angiography and Interventions; Academic Research Consortium-2; Universal Definition of Myocardial Infarction; echocardiograph; upper reference limit; percutaneous coronary interventions; creatine kinase-myocardial band; high-sensitivity cardiac troponin
• ISSN: 0735-1097; 1558-3597; 1558-3597
• DOI: 10.1016/j.jacc.2021.11.047

Definitions of periprocedural myocardial infarction (MI) differ with respect to biomarker threshold as well as ancillary criteria for myocardial ischemia and are limited in terms of validation. This study evaluated the frequency and impact of periprocedural MI by using various MI definitions among patients with chronic coronary syndrome (CCS) undergoing percutaneous coronary intervention (PCI). Between 2010 and 2018, periprocedural MIs were assessed according to the third and fourth Universal Definition of Myocardial Infarction (UDMI), Academic Research Consortium-2 (ARC-2), and Society for Cardiovascular Angiography and Interventions (SCAI) criteria based on high-sensitivity troponin in patients with CCS undergoing PCI enrolled into the Bern PCI registry. The primary endpoint was cardiac death at 1 year. Among 4,404 patients with CCS, periprocedural MI defined by the third UDMI, fourth UDMI, ARC-2, and SCAI were observed in 18.0%, 14.9%, 2.0%, and 2.0% of patients, respectively. Among patients with periprocedural MI defined by the third UDMI, fourth UDMI, ARC-2, and SCAI, cardiac mortality at 1 year was 2.9%, 3.0%, 5.8%, and 10.0%. The ARC-2 (HR: 3.90; 95% CI: 1.54-9.93) and SCAI (HR: 7.66; 95% CI: 3.64-16.11) were more relevant compared with the third UDMI (HR: 1.76; 95% CI: 1.04-3.00) and fourth UDMI (HR: 1.93; 95% CI: 1.11-3.37) for cardiac death at 1 year. Among patients with CCS undergoing PCI, periprocedural MI defined according to the ARC-2 and SCAI criteria was 7 to 9 times less frequent compared with the third and fourth UDMI. Periprocedural MI defined by using the ARC-2 and SCAI were more prognostic for cardiac death at 1 year compared with the third and fourth UDMI. (CARDIOBASE Bern PCI Registry; NCT02241291) [Display omitted]