Resting State fMRI and Improved Deep Learning Algorithm for Earlier Detection of Alzheimer's Disease

• Published in: IEEE access Vol. 8; pp. 115383 - 115392
• Main Authors: Guo, Haibing, Zhang, Yongjin
• Format: Journal Article
• Language: English
• Published: Piscataway IEEE 2020; The Institute of Electrical and Electronics Engineers, Inc. (IEEE)
• Subjects: Aging (natural); Algorithms; Alzheimer's disease; autoencoder network; Brain; Brain modeling; Data models; Deep learning; Diagnosis; Diagnostic systems; Functional magnetic resonance imaging; Health care; improved deep learning algorithm (IDLA); Machine learning; Multimedia; Neural networks; R-fMRI data
• ISSN: 2169-3536; 2169-3536
• DOI: 10.1109/ACCESS.2020.3003424

The development of computerized healthcare has been powered by diagnostic imaging and machine learning techniques. In particular, recent advances in deep learning have opened a new era in support of multimedia healthcare distribution. For earlier detection of Alzheimer's disease, the study suggested the Improved Deep Learning Algorithm (IDLA) and statistically significant text information. The specific information in clinical text includes the age, sex and genes of the person and apolipoprotein E; the brain function is established using resting-state functional data (MRI) for the measurement of connectivity in the brain regions. A specialized network of autoencoders is used in earlier diagnosis to distinguish between natural aging and disorder progression. The suggested approach incorporates effectively biased neural network functionality and allows a reliable Alzheimer's disease recognition. In comparison with conventional classifiers depends on time series R-fMRI results, the proposed deep learning algorithm has improved significantly and, in the best cases, the standard deviation reduced by 45%, indicating the forecast model is more reliable and efficient in relation to conventional methodologies. The work examines the benefits of improved deep learning algorithms from recognizing high-dimensional information in healthcare and can lead to the early diagnosis and prevention of Alzheimer's disease.