Spirometry Versus Forced Oscillation to Assess Lung Function Outcome at 5 Years of Age

• Published in: Pediatric pulmonology Vol. 60; no. 1; pp. e27415 - n/a
• Main Authors: Tepper, Robert S., Milner, Kristin, Harris, Julia, Lee, Brianna, Cunningham, Michelle, Tiller, Christina, Shorey‐Kendrick, Lyndsey E., Schilling, Diane, Brownsberger, Julie, MacDonald, Kelvin, Vu, Annette, Park, Byung S., Spindel, Eliot R., Morris, Cynthia D., McEvoy, Cindy T.
• Format: Journal Article
• Language: English
• Published: United States Wiley Subscription Services, Inc 01.01.2025; John Wiley and Sons Inc
• Subjects: Ascorbic Acid - therapeutic use; Child; Child, Preschool; Female; Humans; Lung - physiopathology; Male; Original; Oscillometry - methods; Pregnancy; Respiratory Function Tests - methods; Respiratory Sounds; Spirometry; Spirometry - methods; Vitamin C
• ISSN: 8755-6863; 1099-0496; 1099-0496
• DOI: 10.1002/ppul.27415

ABSTRACT Background Spirometry is the gold standard for assessing airway function for clinical studies; however, obtaining high‐quality data in young children remains challenging. Since the forced oscillation technique (FOT) requires less subject cooperations, there has been increasing interest in FOT, particularly in young children. We evaluated whether spirometry and FOT in young children provides comparable ability to detect a treatment effect. Methods We recently reported in a randomized controlled trial that vitamin C compared to placebo treatment of mothers who smoked during pregnancy (MSDP) results in the offspring having significantly higher forced expiratory flows (FEFs) at 5‐years of age, as well as significantly less wheeze at 4–6 years of age. In these same offspring, we also measured respiratory impedance using FOT at 8‐Hz impedance at 3, 4, and 5 years of age. Results Although spirometry demonstrated significantly increased FEFs in vitamin C compared to placebo‐treatment group at 5 years of age (p < 0.001), we were not able to detect a similar treatment effect using FOT impedance. Conclusions It may be challenging to obtain technically successful spirometry in preschool children; however, FEFs may provide a better outcome than single‐frequency FOT impedance to assess improvements in airway function in these young subjects.