Synthesis and cytotoxicity studies of novel N -arylbenzo[ h ]quinazolin-2-amines

In this paper, we report a short and efficient synthesis of novel N -arylbenzo[ h ]quinazoline-2-amines. We have prepared a focused library of nineteen representative examples which have been submitted to cytotoxicity assays against a representative panel of eight cancer cell lines and several molec...

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Published inBeilstein journal of organic chemistry Vol. 20; no. 1; pp. 2592 - 2598
Main Authors Veeraiah, Battini, Ramineni, Kishore, Brahmaiah, Dabbugoddu, Kumar, Nangunoori Sampath, Solhi, Hélène, Guevel, Rémy Le, Reddy, Chada Raji, Justaud, Frédéric, Grée, René
Format Journal Article
LanguageEnglish
Published Germany Beilstein-Institut 14.10.2024
Subjects
buchwald–hartwig coupling
Chemical Sciences
Chemistry
cytotoxicity
Full Research Paper
heterocycles
Organic chemistry
pd catalysis
quinazolines
Buchwald–Hartwig coupling
quinazolines
heterocycles
Pd catalysis
cytotoxicity
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ISSN1860-5397
1860-5397
DOI10.3762/bjoc.20.218

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Summary:In this paper, we report a short and efficient synthesis of novel N -arylbenzo[ h ]quinazoline-2-amines. We have prepared a focused library of nineteen representative examples which have been submitted to cytotoxicity assays against a representative panel of eight cancer cell lines and several molecules gave attractive results in this area.
ISSN:1860-5397
1860-5397
DOI:10.3762/bjoc.20.218