Association of Single Nucleotide Polymorphisms of ABCB1,OPRM1 and COMT with Pain Perception in Cancer Patients

• Published in: Journal of Huazhong University of Science and Technology. Medical sciences Vol. 35; no. 5; pp. 752 - 758
• Main Author: 王虚实 宋海斌 陈思 张伟 刘佳琪 黄超 王浩然 陈元 褚倩
• Format: Journal Article
• Language: English
• Published: Wuhan Huazhong University of Science and Technology 01.10.2015; Department of Oncology, Hubei Provincial Hospital of Integrated Chinese and Western Medicine, Wuhan 430000, China%Department of Oncology,Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China%Department of Cardiovascular Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China
• Subjects: Adult; Aged; Aged, 80 and over; Alleles; ATP Binding Cassette Transporter, Sub-Family B - genetics; Breast Neoplasms - complications; Breast Neoplasms - diagnosis; Breast Neoplasms - genetics; Breast Neoplasms - pathology; Catechol O-Methyltransferase - genetics; COMT; Female; Gastrointestinal Neoplasms - complications; Gastrointestinal Neoplasms - diagnosis; Gastrointestinal Neoplasms - genetics; Gastrointestinal Neoplasms - pathology; Gene Expression; Gene Frequency; Genital Neoplasms, Female - complications; Genital Neoplasms, Female - diagnosis; Genital Neoplasms, Female - genetics; Genital Neoplasms, Female - pathology; Genital Neoplasms, Male - complications; Genital Neoplasms, Male - diagnosis; Genital Neoplasms, Male - genetics; Genital Neoplasms, Male - pathology; Genotype; Humans; Lung Neoplasms - complications; Lung Neoplasms - diagnosis; Lung Neoplasms - genetics; Lung Neoplasms - pathology; Male; Medicine; Medicine & Public Health; Middle Aged; Pain - complications; Pain - diagnosis; Pain - genetics; Pain - pathology; Pain Measurement; Pain Perception; Polymorphism, Single Nucleotide; Receptors, Opioid, mu - genetics; 关联; 单核苷酸多态性; 感知; 疼痛; 癌症患者; 癌症病人; 等位基因; cancer pain; ABCB1; OPRM1; pain perception; COMT; single nucleotide polymorphisms (SNPs)
• ISSN: 1672-0733; 1993-1352
• DOI: 10.1007/s11596-015-1502-6

Pain perception is influenced by multiple factors. The single nucleotide polymorphisms（SNPs） of some genes were found associated with pain perception. This study aimed to examine the association of the genotypes of ABCB1 C3435 T,OPRM1 A118 G and COMT V108/158M（valine 108/158 methionine） with pain perception in cancer patients. We genotyped 146 cancer pain patients and 139 cancer patients without pain for ABCB1 C3435T（rs1045642）,OPRM1 A118G（rs1799971） and COMT V108/158M（rs4680） by the fluorescent dye-terminator cycle sequencing method,and compared the genotype distribution between groups with different pain intensities by chi-square test and pain scores between groups with different genotypes by non-parametric test. The results showed that in these cancer patients,the frequency of variant T allele of ABCB1 C3435 T was 40.5%; that of G allele of OPRM1 A118 G was 38.5% and that of A allele of COMT V108/158 M was 23.3%. No significant difference in the genotype distribution of ABCB1 C3435T（rs1045642） and OPRM1 A118G（rs1799971） was observed between cancer pain group and control group（P=0.364 and 0.578）; however,significant difference occurred in the genotype distribution of COMT V108/158M（rs4680） between the two groups（P=0.001）. And the difference could not be explained by any other confounding factors. Moreover,we found that the genotypes of COMT V108/158 M and ABCB1 C3435 T were associated with the intensities of pain in cancer patients. In conclusion,our results indicate that the SNPs of COMT V108/158 M and ABCB1 C3435 T significantly influence the pain perception in Chinese cancer patients.