Sterol 14α-demethylase cytochrome P450 (CYP51), a P450 in all biological kingdoms

The CYP51 family is an intriguing subject for fundamental P450 structure/function studies and is also an important clinical drug target. This review updates information on the variety of the CYP51 family members, including their physiological roles, natural substrates and substrate preferences, and...

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Bibliographic Details
Published inBiochimica et biophysica acta Vol. 1770; no. 3; pp. 467 - 477
Main Authors Lepesheva, Galina I., Waterman, Michael R.
Format Journal Article
LanguageEnglish
Published Elsevier B.V 01.03.2007
Subjects
Catalytic activity
Inhibition
Sterol 14α-demethylase (CYP51)
Sterol biosynthesis
Substrate preferences
Substrate preferences
Catalytic activity
Sterol biosynthesis
Sterol 14α-demethylase (CYP51)
Inhibition
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ISSN0304-4165
0006-3002
1872-8006
DOI10.1016/j.bbagen.2006.07.018

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Summary:The CYP51 family is an intriguing subject for fundamental P450 structure/function studies and is also an important clinical drug target. This review updates information on the variety of the CYP51 family members, including their physiological roles, natural substrates and substrate preferences, and catalytic properties in vitro. We present experimental support for the notion that specific conserved regions in the P450 sequences represent a CYP51 signature. Two possible roles of CYP51 in P450 evolution are discussed and the major approaches for CYP51 inhibition are summarized.
Bibliography:Corresponding author: Michael R. Waterman, Tel.: 615-343-1373; Fax: 615-322-4349; E-mail: michael.waterman@vanderbilt.edu
ISSN:0304-4165
0006-3002
1872-8006
DOI:10.1016/j.bbagen.2006.07.018