Histopathological Features of Invasion of Breast Invasive Ductal Carcinoma and Safety of Breast-conserving Surgery

• Published in: Journal of Huazhong University of Science and Technology. Medical sciences Vol. 29; no. 1; pp. 50 - 52
• Main Author: 刘春萍 潘华雄 李治 石岚 黄韬
• Format: Journal Article
• Language: English
• Published: Heidelberg Huazhong University of Science and Technology 01.02.2009; Department of Breast and Thyroid Surgery,Union Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430022,China
• Subjects: Adolescent; Adult; Aged; Axilla; Breast Neoplasms - metabolism; Breast Neoplasms - pathology; Breast Neoplasms - surgery; Carcinoma, Ductal, Breast - metabolism; Carcinoma, Ductal, Breast - pathology; Carcinoma, Ductal, Breast - surgery; Female; Humans; Lymph Nodes - pathology; Lymphatic Metastasis; Mastectomy - methods; Medicine; Medicine & Public Health; Middle Aged; Neoplasm Invasiveness; Receptor, ErbB-2 - genetics; Receptor, ErbB-2 - metabolism; Young Adult; 乳腺浸润性导管癌; 保乳手术; 基因过度表达; 安全性; 组织病理学特征; 肿瘤大小; 腋窝淋巴结转移; breast neoplasm; mastectomy, segmental; tumor invasion; mastectomy,segmental
• ISSN: 1672-0733; 1993-1352
• DOI: 10.1007/s11596-009-0110-8

In order to investigate the relationship between the extent of tumor invasion and the tumor size, axillary lymph nodes metastasis, Her-2 gene overexpression, and histologic grading in breast invasive ductal carcinoma as well as the optimal extent of excision during the breast-serving surgery, the clinical data of 104 patients with breast invasive ductal carcinoma who had received modified radical mastectomy were analyzed. The correlation analysis on invasive extent, which was evaluated by serial sections at an interval of 0.5 cm from 4 different directions taking the focus as the centre, and the tumor size, axillary lymph nodes metastasis, Her-2 gene overexpression, and his- tologic grading was processed. There was a significant correlation between invasive extent and tumor size （r=-0.766, P〈0.01）, and lymph nodes metastases 0=0.574, P〈0.01）, but there was no significant correlation between invasive extent and Her-2 expression （r=-0.106, P〉0.05）, and histologic grading （r=-0.228, P〉0.05）. The 100% negative rate of infiltration in patients without nipple discharge with tumor size 〈2, 2-3 and 〉3 cm was obtained at 1.5, 2.0 and 2.5 cm away from the tumor respectively. It is concluded that the performance of breast-serving surgery in patients with breast invasive ductal carcinoma should be evaluated by tumor size in combination with axillary lymph nodes involvement to decide the possibility of breast-serving and the secure excision extent.