Seeing the world through the eyes of cultured cells
The metabolic environment experienced by cultured cells often differs from physiological conditions. Here, we highlight the effects that the microenvironment can have on cultured cell behavior and advocate for researchers to re-evaluate culture practices to enhance the relevance and translational po...
Saved in:
| Published in | Cell metabolism Vol. 37; no. 4; pp. 802 - 805 |
|---|---|
| Main Authors | , , , , |
| Format | Journal Article |
| Language | English |
| Published |
United States
Elsevier Inc
01.04.2025
|
| Subjects | |
| Online Access | Get full text |
| ISSN | 1550-4131 1932-7420 1932-7420 |
| DOI | 10.1016/j.cmet.2025.01.027 |
Cover
| Abstract | The metabolic environment experienced by cultured cells often differs from physiological conditions. Here, we highlight the effects that the microenvironment can have on cultured cell behavior and advocate for researchers to re-evaluate culture practices to enhance the relevance and translational potential of in vitro studies.
[Display omitted]
The metabolic environment experienced by cultured cells often differs from physiological conditions. Here, we highlight the effects that the microenvironment can have on cultured cell behavior and advocate for researchers to re-evaluate culture practices to enhance the relevance and translational potential of in vitro studies. |
|---|---|
| AbstractList | The metabolic environment experienced by cultured cells often differs from physiological conditions. Here we highlight the effects that the microenvironment can have on cultured cell behavior, and advocate for researchers to re-evaluate culture practices to enhance the relevance and translational potential of in vitro studies. The metabolic environment experienced by cultured cells often differs from physiological conditions. Here, we highlight the effects that the microenvironment can have on cultured cell behavior and advocate for researchers to re-evaluate culture practices to enhance the relevance and translational potential of in vitro studies. [Display omitted] The metabolic environment experienced by cultured cells often differs from physiological conditions. Here, we highlight the effects that the microenvironment can have on cultured cell behavior and advocate for researchers to re-evaluate culture practices to enhance the relevance and translational potential of in vitro studies. The metabolic environment experienced by cultured cells often differs from physiological conditions. Here, we highlight the effects that the microenvironment can have on cultured cell behavior and advocate for researchers to re-evaluate culture practices to enhance the relevance and translational potential of in vitro studies. The metabolic environment experienced by cultured cells often differs from physiological conditions. Here, we highlight the effects that the microenvironment can have on cultured cell behavior and advocate for researchers to re-evaluate culture practices to enhance the relevance and translational potential of in vitro studies.The metabolic environment experienced by cultured cells often differs from physiological conditions. Here, we highlight the effects that the microenvironment can have on cultured cell behavior and advocate for researchers to re-evaluate culture practices to enhance the relevance and translational potential of in vitro studies. |
| Author | Kunzmann, Guy B. Cantor, Jason R. Virtue, Sam Fazakerley, Daniel J. Tan, Joycelyn |
| AuthorAffiliation | 1 Metabolic Research Laboratories, https://ror.org/0264dxb48 Institute of Metabolic Science , https://ror.org/013meh722 University of Cambridge , Cambridge CB2 0QQ , UK 6 https://ror.org/01e4byj08 University of Wisconsin Carbone Cancer Center , Madison , WI , USA 3 Department of Biochemistry, https://ror.org/01y2jtd41 University of Wisconsin-Madison , Madison , WI , USA 2 https://ror.org/05cb4rb43 Morgridge Institute for Research , Madison , WI , USA 4 No current affiliation 5 Department of Biomedical Engineering, https://ror.org/01y2jtd41 University of Wisconsin-Madison , Madison , WI , USA |
| AuthorAffiliation_xml | – name: 2 https://ror.org/05cb4rb43 Morgridge Institute for Research , Madison , WI , USA – name: 6 https://ror.org/01e4byj08 University of Wisconsin Carbone Cancer Center , Madison , WI , USA – name: 1 Metabolic Research Laboratories, https://ror.org/0264dxb48 Institute of Metabolic Science , https://ror.org/013meh722 University of Cambridge , Cambridge CB2 0QQ , UK – name: 4 No current affiliation – name: 3 Department of Biochemistry, https://ror.org/01y2jtd41 University of Wisconsin-Madison , Madison , WI , USA – name: 5 Department of Biomedical Engineering, https://ror.org/01y2jtd41 University of Wisconsin-Madison , Madison , WI , USA |
| Author_xml | – sequence: 1 givenname: Joycelyn surname: Tan fullname: Tan, Joycelyn organization: Metabolic Research Laboratories, Institute of Metabolic Science, University of Cambridge, Cambridge CB2 0QQ, UK – sequence: 2 givenname: Guy B. surname: Kunzmann fullname: Kunzmann, Guy B. organization: Morgridge Institute for Research, Madison, WI, USA – sequence: 3 givenname: Sam surname: Virtue fullname: Virtue, Sam organization: Much Hadham, UK – sequence: 4 givenname: Jason R. surname: Cantor fullname: Cantor, Jason R. email: jcantor@morgridge.org organization: Morgridge Institute for Research, Madison, WI, USA – sequence: 5 givenname: Daniel J. surname: Fazakerley fullname: Fazakerley, Daniel J. email: djf72@cam.ac.uk organization: Metabolic Research Laboratories, Institute of Metabolic Science, University of Cambridge, Cambridge CB2 0QQ, UK |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/40081370$$D View this record in MEDLINE/PubMed |
| BookMark | eNqNkE1P3DAQhq1qER9b_gAHlGMvSccfiYlUVaoQ0EorcYCeLcee7HqVjRc7WbT_noQApRfEySPPPO9onhMya32LhJxRyCjQ4vs6MxvsMgYsz4BmwOQXckxLzlIpGMyGOs8hFZTTI3IS4xqAF7zkh-RIAFxQLuGY8DtE1y6TboXJow-NHarg--Xq-Qf3GBNfJ6Zvuj6gTQw2TfxKDmrdRDx9eefk7_XV_eXvdHF78-fy1yI1AoouLWrJKllaK3RdaLCyFohVzkUFzBgEY3QtmNRc15AXVGhpUWhTioqiQU75nPApt2-3ev-om0Ztg9vosFcU1KhArdWoQI0KFFA1KBionxO17asNWoNtF_Q_0mun_u-0bqWWfqdkQWVRXgwB314Cgn_oMXZq4-J4uG7R91FxKiXN2WhwTs7f73pb8up3GGDTgAk-xoD15y74MUE4yN05DCoah61B6wKaTlnvPsKfAGiMpNc |
| Cites_doi | 10.1126/science.122.3168.501 10.1016/j.cell.2014.06.007 10.1096/fj.09-151803 10.1016/j.cell.2017.03.023 10.1016/j.isci.2019.100759 10.1016/j.bbalip.2013.10.013 10.1016/j.plipres.2019.101017 10.1038/s44318-024-00084-7 10.1194/jlr.M083030 10.1126/sciadv.aau7314 10.1016/j.tcb.2019.08.009 10.1016/j.cmet.2022.07.012 10.1126/science.130.3373.432 10.1016/j.cmet.2021.02.005 |
| ContentType | Journal Article |
| Copyright | 2025 Elsevier Inc. Copyright © 2025 Elsevier Inc. All rights reserved. |
| Copyright_xml | – notice: 2025 Elsevier Inc. – notice: Copyright © 2025 Elsevier Inc. All rights reserved. |
| DBID | AAYXX CITATION CGR CUY CVF ECM EIF NPM 7X8 5PM ADTOC UNPAY |
| DOI | 10.1016/j.cmet.2025.01.027 |
| DatabaseName | CrossRef Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed MEDLINE - Academic PubMed Central (Full Participant titles) Unpaywall for CDI: Periodical Content Unpaywall |
| DatabaseTitle | CrossRef MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) MEDLINE - Academic |
| DatabaseTitleList | MEDLINE MEDLINE - Academic |
| Database_xml | – sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database – sequence: 3 dbid: UNPAY name: Unpaywall url: https://proxy.k.utb.cz/login?url=https://unpaywall.org/ sourceTypes: Open Access Repository |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Biology |
| EISSN | 1932-7420 |
| EndPage | 805 |
| ExternalDocumentID | oai:pubmedcentral.nih.gov:7617698 PMC7617698 40081370 10_1016_j_cmet_2025_01_027 S1550413125000518 |
| Genre | Journal Article Review |
| GrantInformation_xml | – fundername: Medical Research Council grantid: MR/S007091/1 |
| GroupedDBID | --- --K 0R~ 1~5 29B 4.4 457 4G. 5GY 62- 6J9 7-5 AAEDT AAEDW AAKRW AAKUH AALRI AAMRU AAVLU AAXUO AAYWO ABDGV ABJNI ABMAC ACGFO ACGFS ADBBV ADEZE AEFWE AENEX AFTJW AGCQF AGKMS AITUG AKAPO AKRWK ALMA_UNASSIGNED_HOLDINGS AMRAJ APXCP ASPBG AVWKF AZFZN BAWUL CS3 DIK DU5 E3Z EBS F5P FCP FDB FEDTE FIRID HVGLF IHE IXB J1W JIG M3Z M41 O-L O9- OK1 P2P ROL RPZ SES TR2 UNMZH 2WC 53G AAIKJ AAYXX ACVFH ADCNI ADVLN AEUPX AEXQZ AFPUW AGHFR AIGII AKBMS AKYEP CITATION EFKBS EJD HZ~ OZT SSZ CGR CUY CVF ECM EIF NPM 7X8 5PM ADTOC UNPAY |
| ID | FETCH-LOGICAL-c406t-6f72b79dd4af6a0d7f4eeb534b02cce0ccaf427a3af05614a7de4ac94b1ece313 |
| IEDL.DBID | UNPAY |
| ISSN | 1550-4131 1932-7420 |
| IngestDate | Tue Aug 19 09:14:40 EDT 2025 Tue Sep 30 17:03:12 EDT 2025 Sun Sep 28 11:04:53 EDT 2025 Sat May 31 02:14:00 EDT 2025 Wed Oct 01 06:02:32 EDT 2025 Sat Jun 21 16:51:45 EDT 2025 |
| IsDoiOpenAccess | true |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 4 |
| Language | English |
| License | Copyright © 2025 Elsevier Inc. All rights reserved. This work is licensed under a BY 4.0 International license. cc-by |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c406t-6f72b79dd4af6a0d7f4eeb534b02cce0ccaf427a3af05614a7de4ac94b1ece313 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 Lead contact |
| OpenAccessLink | https://proxy.k.utb.cz/login?url=https://www.ncbi.nlm.nih.gov/pmc/articles/7617698 |
| PMID | 40081370 |
| PQID | 3177152081 |
| PQPubID | 23479 |
| PageCount | 4 |
| ParticipantIDs | unpaywall_primary_10_1016_j_cmet_2025_01_027 pubmedcentral_primary_oai_pubmedcentral_nih_gov_7617698 proquest_miscellaneous_3177152081 pubmed_primary_40081370 crossref_primary_10_1016_j_cmet_2025_01_027 elsevier_sciencedirect_doi_10_1016_j_cmet_2025_01_027 |
| ProviderPackageCode | CITATION AAYXX |
| PublicationCentury | 2000 |
| PublicationDate | 2025-04-01 |
| PublicationDateYYYYMMDD | 2025-04-01 |
| PublicationDate_xml | – month: 04 year: 2025 text: 2025-04-01 day: 01 |
| PublicationDecade | 2020 |
| PublicationPlace | United States |
| PublicationPlace_xml | – name: United States |
| PublicationTitle | Cell metabolism |
| PublicationTitleAlternate | Cell Metab |
| PublicationYear | 2025 |
| Publisher | Elsevier Inc |
| Publisher_xml | – name: Elsevier Inc |
| References | Saab, Dzierozynski, Jonker, Aminitabrizi, Shah, Menjivar, Scott, Nwosu, Zhu, Chen (bib15) 2023; 12 Eagle (bib11) 1959; 130 Pekkurnaz, Trinidad, Wang, Kong, Schwarz (bib5) 2014; 158 Cantor (bib12) 2019; 29 Leney-Greene, Boddapati, Su, Cantor, Lenardo (bib9) 2020; 23 Voorde Vande, Ackermann, Pfetzer, Sumpton, Mackay, Kalna, Nixon, Blyth, Gottlieb, Tardito (bib13) 2019; 5 Okuno, Gijón, Zarini, Martin, Barkley, Johnson, Ohba, Yokomizo, Murphy (bib4) 2018; 59 Eagle (bib1) 1955; 122 Mailloux, Harper (bib6) 2010; 24 Rossiter, Huggler, Adelmann, Keys, Soens, Sabatini, Cantor (bib8) 2021; 33 Tan, Virtue, Norris, Conway, Yang, Bidault, Gribben, Lugtu, Kamzolas, Krycer (bib10) 2024; 43 Kaymak, Luda, Duimstra, Ma, Longo, Dahabieh, Faubert, Oswald, Watson, Kitchen-Goosen (bib14) 2022; 34 Else (bib2) 2020; 77 Ichi, Kono, Arita, Haga, Arisawa, Yamano, Nagase, Fujiwara, Arai (bib3) 2014; 1841 Cantor, Abu-Remaileh, Kanarek, Freinkman, Gao, Louissaint, Lewis, Sabatini (bib7) 2017; 169 Eagle (10.1016/j.cmet.2025.01.027_bib11) 1959; 130 Eagle (10.1016/j.cmet.2025.01.027_bib1) 1955; 122 Voorde Vande (10.1016/j.cmet.2025.01.027_bib13) 2019; 5 Rossiter (10.1016/j.cmet.2025.01.027_bib8) 2021; 33 Pekkurnaz (10.1016/j.cmet.2025.01.027_bib5) 2014; 158 Cantor (10.1016/j.cmet.2025.01.027_bib7) 2017; 169 Leney-Greene (10.1016/j.cmet.2025.01.027_bib9) 2020; 23 Kaymak (10.1016/j.cmet.2025.01.027_bib14) 2022; 34 Ichi (10.1016/j.cmet.2025.01.027_bib3) 2014; 1841 Okuno (10.1016/j.cmet.2025.01.027_bib4) 2018; 59 Cantor (10.1016/j.cmet.2025.01.027_bib12) 2019; 29 Else (10.1016/j.cmet.2025.01.027_bib2) 2020; 77 Tan (10.1016/j.cmet.2025.01.027_bib10) 2024; 43 Mailloux (10.1016/j.cmet.2025.01.027_bib6) 2010; 24 Saab (10.1016/j.cmet.2025.01.027_bib15) 2023; 12 |
| References_xml | – volume: 122 start-page: 501 year: 1955 end-page: 504 ident: bib1 article-title: Nutrition needs of mammalian cells in tissue culture publication-title: Science – volume: 158 start-page: 54 year: 2014 end-page: 68 ident: bib5 article-title: Glucose Regulates Mitochondrial Motility via Milton Modification by O-GlcNAc Transferase publication-title: Cell – volume: 29 start-page: 854 year: 2019 end-page: 861 ident: bib12 article-title: The Rise of Physiologic Media publication-title: Trends Cell Biol. – volume: 24 start-page: 2495 year: 2010 end-page: 2506 ident: bib6 article-title: Glucose regulates enzymatic sources of mitochondrial NADPH in skeletal muscle cells; a novel role for glucose-6-phosphate dehydrogenase publication-title: FASEB J. – volume: 130 start-page: 432 year: 1959 end-page: 437 ident: bib11 article-title: Amino acid metabolism in mammalian cell cultures publication-title: Science – volume: 33 start-page: 1248 year: 2021 end-page: 1263.e9 ident: bib8 article-title: CRISPR screens in physiologic medium reveal conditionally essential genes in human cells publication-title: Cell Metab. – volume: 34 start-page: 1298 year: 2022 end-page: 1311.e6 ident: bib14 article-title: Carbon source availability drives nutrient utilization in CD8 publication-title: Cell Metab. – volume: 77 start-page: 101017 year: 2020 ident: bib2 article-title: The highly unnatural fatty acid profile of cells in culture publication-title: Prog. Lipid Res. – volume: 59 start-page: 542 year: 2018 end-page: 549 ident: bib4 article-title: Altered eicosanoid production and phospholipid remodeling during cell culture publication-title: J. Lipid Res. – volume: 5 year: 2019 ident: bib13 article-title: Improving the metabolic fidelity of cancer models with a physiological cell culture medium publication-title: Sci. Adv. – volume: 12 year: 2023 ident: bib15 article-title: Pancreatic tumors exhibit myeloid-driven amino acid stress and upregulate arginine biosynthesis publication-title: eLife – volume: 23 year: 2020 ident: bib9 article-title: Human Plasma-like Medium Improves T Lymphocyte Activation publication-title: iScience – volume: 43 start-page: 2127 year: 2024 end-page: 2165 ident: bib10 article-title: Limited oxygen in standard cell culture alters metabolism and function of differentiated cells publication-title: EMBO J. – volume: 169 start-page: 258 year: 2017 end-page: 272.e17 ident: bib7 article-title: Physiologic Medium Rewires Cellular Metabolism and Reveals Uric Acid as an Endogenous Inhibitor of UMP Synthase publication-title: Cell – volume: 1841 start-page: 204 year: 2014 end-page: 213 ident: bib3 article-title: Identification of genes and pathways involved in the synthesis of Mead acid (20:3n-9), an indicator of essential fatty acid deficiency publication-title: Biochim. Biophys. Acta – volume: 122 start-page: 501 year: 1955 ident: 10.1016/j.cmet.2025.01.027_bib1 article-title: Nutrition needs of mammalian cells in tissue culture publication-title: Science doi: 10.1126/science.122.3168.501 – volume: 158 start-page: 54 year: 2014 ident: 10.1016/j.cmet.2025.01.027_bib5 article-title: Glucose Regulates Mitochondrial Motility via Milton Modification by O-GlcNAc Transferase publication-title: Cell doi: 10.1016/j.cell.2014.06.007 – volume: 24 start-page: 2495 year: 2010 ident: 10.1016/j.cmet.2025.01.027_bib6 article-title: Glucose regulates enzymatic sources of mitochondrial NADPH in skeletal muscle cells; a novel role for glucose-6-phosphate dehydrogenase publication-title: FASEB J. doi: 10.1096/fj.09-151803 – volume: 169 start-page: 258 year: 2017 ident: 10.1016/j.cmet.2025.01.027_bib7 article-title: Physiologic Medium Rewires Cellular Metabolism and Reveals Uric Acid as an Endogenous Inhibitor of UMP Synthase publication-title: Cell doi: 10.1016/j.cell.2017.03.023 – volume: 23 year: 2020 ident: 10.1016/j.cmet.2025.01.027_bib9 article-title: Human Plasma-like Medium Improves T Lymphocyte Activation publication-title: iScience doi: 10.1016/j.isci.2019.100759 – volume: 1841 start-page: 204 year: 2014 ident: 10.1016/j.cmet.2025.01.027_bib3 article-title: Identification of genes and pathways involved in the synthesis of Mead acid (20:3n-9), an indicator of essential fatty acid deficiency publication-title: Biochim. Biophys. Acta doi: 10.1016/j.bbalip.2013.10.013 – volume: 77 start-page: 101017 year: 2020 ident: 10.1016/j.cmet.2025.01.027_bib2 article-title: The highly unnatural fatty acid profile of cells in culture publication-title: Prog. Lipid Res. doi: 10.1016/j.plipres.2019.101017 – volume: 43 start-page: 2127 year: 2024 ident: 10.1016/j.cmet.2025.01.027_bib10 article-title: Limited oxygen in standard cell culture alters metabolism and function of differentiated cells publication-title: EMBO J. doi: 10.1038/s44318-024-00084-7 – volume: 59 start-page: 542 year: 2018 ident: 10.1016/j.cmet.2025.01.027_bib4 article-title: Altered eicosanoid production and phospholipid remodeling during cell culture publication-title: J. Lipid Res. doi: 10.1194/jlr.M083030 – volume: 5 year: 2019 ident: 10.1016/j.cmet.2025.01.027_bib13 article-title: Improving the metabolic fidelity of cancer models with a physiological cell culture medium publication-title: Sci. Adv. doi: 10.1126/sciadv.aau7314 – volume: 29 start-page: 854 year: 2019 ident: 10.1016/j.cmet.2025.01.027_bib12 article-title: The Rise of Physiologic Media publication-title: Trends Cell Biol. doi: 10.1016/j.tcb.2019.08.009 – volume: 34 start-page: 1298 year: 2022 ident: 10.1016/j.cmet.2025.01.027_bib14 article-title: Carbon source availability drives nutrient utilization in CD8+ T cells publication-title: Cell Metab. doi: 10.1016/j.cmet.2022.07.012 – volume: 130 start-page: 432 year: 1959 ident: 10.1016/j.cmet.2025.01.027_bib11 article-title: Amino acid metabolism in mammalian cell cultures publication-title: Science doi: 10.1126/science.130.3373.432 – volume: 33 start-page: 1248 year: 2021 ident: 10.1016/j.cmet.2025.01.027_bib8 article-title: CRISPR screens in physiologic medium reveal conditionally essential genes in human cells publication-title: Cell Metab. doi: 10.1016/j.cmet.2021.02.005 – volume: 12 year: 2023 ident: 10.1016/j.cmet.2025.01.027_bib15 article-title: Pancreatic tumors exhibit myeloid-driven amino acid stress and upregulate arginine biosynthesis publication-title: eLife |
| SSID | ssj0036393 |
| Score | 2.4739819 |
| SecondaryResourceType | review_article |
| Snippet | The metabolic environment experienced by cultured cells often differs from physiological conditions. Here, we highlight the effects that the microenvironment... The metabolic environment experienced by cultured cells often differs from physiological conditions. Here we highlight the effects that the microenvironment... |
| SourceID | unpaywall pubmedcentral proquest pubmed crossref elsevier |
| SourceType | Open Access Repository Aggregation Database Index Database Publisher |
| StartPage | 802 |
| SubjectTerms | Animals Cell Culture Techniques - methods Cells, Cultured Cellular Microenvironment Humans |
| Title | Seeing the world through the eyes of cultured cells |
| URI | https://dx.doi.org/10.1016/j.cmet.2025.01.027 https://www.ncbi.nlm.nih.gov/pubmed/40081370 https://www.proquest.com/docview/3177152081 https://pubmed.ncbi.nlm.nih.gov/PMC7617698 https://www.ncbi.nlm.nih.gov/pmc/articles/7617698 |
| UnpaywallVersion | submittedVersion |
| Volume | 37 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| journalDatabaseRights | – providerCode: PRVLSH databaseName: Elsevier Journals customDbUrl: mediaType: online eissn: 1932-7420 dateEnd: 99991231 omitProxy: true ssIdentifier: ssj0036393 issn: 1550-4131 databaseCode: AKRWK dateStart: 20050101 isFulltext: true providerName: Library Specific Holdings |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwlV1db9MwFL0arRB74ZsRGFOQeGNpk9iJk8cKrZqYVKFCxfZk2c6N2NamFW2Ful-_6zipGBWIPSZ2rDgn9j2Wj88F-GAoqgueF4FI85QWKIoFWRSZgCc6Y2WWJaWu1Raj9HTCP58n53sQtWdhatG-0Ze9ajrrVZc_am3lYmb6rU6sT-tuajd7AN3U7il1oDsZfRlc1L6oSRjQpBy5nWRijjwOm4MyTtNlZmj1k3Fj1Sn-Fox2yeauZvLRulqozS81nf4WkIZPYNx2xelQrnvrle6Zmz9cHu_V16fwuKGn_sAVPYM9rJ7DQ5ewcvMC2FdEinU-sUa_9lr1mzw_9R3c4NKfl75z88DCt7sCy5cwGZ58-3QaNGkXAkPRfRWkpYi1yIuCqzJVYSFKjqgTxnUYG4MhYV7yWCimytpHVIkCuTI51xEaZBF7BZ1qXuFr8JHp3ObDojVnwTEt8tjQColTiyrjGaIHH9vvLxfOXUO2srMradGSFi0ZRpLQ8iBpIZINP3BxX9L0_8_n3rd4Sho8tu-qwvl6KYk8CSIwRIs8OHD4bt-DW7bEROiBuIP8toI15r5bQhjWBt0NbB4cb_-R_-jem_tVfwv79sqpiA6hs_q5xndEkFb6CLqDs_H3s6NmaNwCODMQhQ |
| linkProvider | Unpaywall |
| linkToUnpaywall | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwlV1bS-QwFD64I8vui5e9WW90Yd-0Y9ukTfsooogPIuqA-xSS9BQvM51hZwYZf70nTTvoiqKPbdLQ9GtyvpAv3wH4YyiqC54XgUjzlBYoigVZFJmAJzpjZZYlpa7VFqfpcY-fXCVXCxC1Z2Fq0b7RN92qP-hWN9e1tnI0MHutTmyP1t3UbvYJFlO7p9SBxd7p2f7f2hc1CQOalCO3k0zMkcdhc1DGabrMAK1-Mm6sOsVrwegl2XypmfwyrUZqdq_6_ScB6WgZztuuOB3KXXc60V3z8J_L44f6ugJLDT31913RKixg9Q0-u4SVs-_ALhAp1vnEGv3aa9Vv8vzUd3CGY39Y-s7NAwvf7gqMf0Dv6PDy4Dho0i4EhqL7JEhLEWuRFwVXZarCQpQcUSeM6zA2BkPCvOSxUEyVtY-oEgVyZXKuIzTIIvYTOtWwwjXwkenc5sOiNWfBMS3y2NAKiVOLKuMZogc77feXI-euIVvZ2a20aEmLlgwjSWh5kLQQyYYfuLgvafp_87nfLZ6SBo_tu6pwOB1LIk-CCAzRIg9-OXzn78EtW2Ii9EA8Q35ewRpzPy8hDGuD7gY2D3bn_8g7urf-seob8NVeORXRJnQm_6a4RQRporebIfEIvA4O4g |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Seeing+the+world+through+the+eyes+of+cultured+cells&rft.jtitle=Cell+metabolism&rft.au=Tan%2C+Joycelyn&rft.au=Kunzmann%2C+Guy+B&rft.au=Virtue%2C+Sam&rft.au=Cantor%2C+Jason+R&rft.date=2025-04-01&rft.issn=1932-7420&rft.eissn=1932-7420&rft.volume=37&rft.issue=4&rft.spage=802&rft_id=info:doi/10.1016%2Fj.cmet.2025.01.027&rft.externalDBID=NO_FULL_TEXT |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1550-4131&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1550-4131&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1550-4131&client=summon |