Seeing the world through the eyes of cultured cells

The metabolic environment experienced by cultured cells often differs from physiological conditions. Here, we highlight the effects that the microenvironment can have on cultured cell behavior and advocate for researchers to re-evaluate culture practices to enhance the relevance and translational po...

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Published inCell metabolism Vol. 37; no. 4; pp. 802 - 805
Main Authors Tan, Joycelyn, Kunzmann, Guy B., Virtue, Sam, Cantor, Jason R., Fazakerley, Daniel J.
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 01.04.2025
Subjects
Animals
Cell Culture Techniques - methods
Cells, Cultured
Cellular Microenvironment
Humans
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ISSN1550-4131
1932-7420
1932-7420
DOI10.1016/j.cmet.2025.01.027

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Summary:The metabolic environment experienced by cultured cells often differs from physiological conditions. Here, we highlight the effects that the microenvironment can have on cultured cell behavior and advocate for researchers to re-evaluate culture practices to enhance the relevance and translational potential of in vitro studies. [Display omitted] The metabolic environment experienced by cultured cells often differs from physiological conditions. Here, we highlight the effects that the microenvironment can have on cultured cell behavior and advocate for researchers to re-evaluate culture practices to enhance the relevance and translational potential of in vitro studies.
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ISSN:1550-4131
1932-7420
1932-7420
DOI:10.1016/j.cmet.2025.01.027