Toxicity of Diclofenac: Cadmium Binary Mixtures to Algae Desmodesmus subspicatus Using Normalization Method

• Published in: Bulletin of environmental contamination and toxicology Vol. 101; no. 2; pp. 205 - 213
• Main Authors: Doležalová Weissmannová, Helena, Pavlovský, Jiří, Fišerová, Lenka, Kosárová, Hedvika
• Format: Journal Article
• Language: English
• Published: New York Springer US 01.08.2018; Springer Nature B.V
• Subjects: Acute toxicity; Algae; Aquatic Pollution; Binary mixtures; Cadmium; Desmodesmus; Diclofenac; Earth and Environmental Science; Ecotoxicology; Environment; Environmental Chemistry; Environmental Health; Nonsteroidal anti-inflammatory drugs; Organic chemistry; Pollution; Soil Science & Conservation; Toxicity; Toxicity testing; Waste Water Technology; Water Management; Water Pollution Control; Waterborne diseases; Cadmium; Binary mixtures; Normalization method; Diclofenac; Desmodesmus subspicatus
• ISSN: 0007-4861; 1432-0800; 1432-0800
• DOI: 10.1007/s00128-018-2384-7

Algal test using chlorococcal algae Desmodesmus subspicatus was used to determine single acute toxicity of either diclofenac or cadmium and to assess acute toxicity of their binary mixtures. The test confirmed significant acute toxicity of both diclofenac and cadmium; diclofenac with acute toxicity E r C50 60.44 ± 0.20 mg/L and cadmium with acute toxicity E r C50 2.14 ± 0.02 mg/L. This study of acute toxicity of binary cadmium-diclofenac mixtures confirmed their negative effects on aquatic producers and it also proved influence of the above substances on acute toxicity of their mixtures. Normalization method was applied to predict acute toxicity of binary mixtures composed of chemicals with significantly different acute toxicities. Normalization method used molar ratio (R) of chemicals in binary mixtures as their composition descriptor.