Rapid Alternate Monocular Deprivation Does Not Affect Binocular Balance and Correlation in Human Adults

Recent studies show that the human adult visual system exhibits neural plasticity. For instance, short-term monocular deprivation shifts the eye dominance in favor of the deprived eye. This phenomenon is believed to occur in the primary visual cortex by reinstating neural plasticity. However, it is...

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Published ineNeuro Vol. 9; no. 3; p. ENEURO.0509-21.2022
Main Authors Lin (林温曼), Wenman, Wei (魏君涵), Junhan, Wang (王文静), Wenjing, Zou (邹李颖), Liying, Zhou (周诗旗), Shiqi, Jiang (江楠), Nan, Reynaud, Alexandre, Zhou (周佳玮), Jiawei, Yu (于旭东), Xudong, Hess, Robert F.
Format Journal Article
LanguageEnglish
Published United States Society for Neuroscience 01.05.2022
Subjects
New Research
binocular balance
interocular correlation
flicker
visual plasticity
visual deprivation
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ISSN2373-2822
2373-2822
DOI10.1523/ENEURO.0509-21.2022

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Summary:Recent studies show that the human adult visual system exhibits neural plasticity. For instance, short-term monocular deprivation shifts the eye dominance in favor of the deprived eye. This phenomenon is believed to occur in the primary visual cortex by reinstating neural plasticity. However, it is unknown whether the changes in eye dominance after monocularly depriving the visual input can also be induced by alternately depriving both eyes. In this study, we found no changes in binocular balance and interocular correlation sensitivity after a rapid (7 Hz), alternate, and monocular deprivation for 1 h in adults. Therefore, the effect of short-term monocular deprivation cannot seem to be emulated by alternately and rapidly depriving both eyes.
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Author contributions: W.L., J.Z., and X.Y. designed research; W.L., J.W., W.W., L.Z., S.Z., and N.J. performed research; W.L., A.R., J.Z., X.Y., and R.F.H. analyzed data; W.L., A.R., J.Z., X.Y., and R.F.H. wrote the paper.
This work was supported by the National Natural Science Foundation of China Grant NSFC31970975, the Natural Science Foundation for Distinguished Young Scholars of Zhejiang Province, China, Grant LR22H120001, and the Project of State Key Laboratory of Ophthalmology, Optometry and Vision Science, Wenzhou Medical University Grant J02-20210203 to J.Z.; the Scientific Research Fund of Zhejiang Provincial Education Department Grant Y202045473 to W.L.; and Natural Sciences and Engineering Research Council of Canada Grant 228103 and Network of European Funding for Neuroscience Research. (ERA-NET Neuron) Grant JTC2015 to R.F.H.
The authors declare no competing financial interests.
ISSN:2373-2822
2373-2822
DOI:10.1523/ENEURO.0509-21.2022